TY - JOUR
T1 - Transient and long-term differential modulations of branched-chain α-keto acid decarboxylase activity in hypophysectomized rats
AU - Sullivan, Stephen Gene
AU - Dancis, Joseph
AU - Cox, Rody P.
N1 - Funding Information:
This study was supported by the National Institutes of Health and the Samuel A. Berger Foundation.
PY - 1978/3/1
Y1 - 1978/3/1
N2 - Hypophysectomy caused a marked but transient increase in branched-chain α-keto acid decarboxylase activities in rat liver mitochondria, peaking at about nine days post-surgery. The magnitude of increase is different for each of the three branched-chain α-keto acids. The activities then fall to a new steady state in three weeks with α-ketoisovalerate decarboxylase activity within the normal range, α-keto-β-methylvalerate decarboxylase activity at twice normal, and α-ketoisocaproate decarboxylase activity decreased to a level too low for accurate measurements.
AB - Hypophysectomy caused a marked but transient increase in branched-chain α-keto acid decarboxylase activities in rat liver mitochondria, peaking at about nine days post-surgery. The magnitude of increase is different for each of the three branched-chain α-keto acids. The activities then fall to a new steady state in three weeks with α-ketoisovalerate decarboxylase activity within the normal range, α-keto-β-methylvalerate decarboxylase activity at twice normal, and α-ketoisocaproate decarboxylase activity decreased to a level too low for accurate measurements.
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U2 - 10.1016/0304-4165(78)90001-6
DO - 10.1016/0304-4165(78)90001-6
M3 - Article
C2 - 629995
AN - SCOPUS:0018187481
SN - 0304-4165
VL - 539
SP - 135
EP - 141
JO - BBA - General Subjects
JF - BBA - General Subjects
IS - 2
ER -