Transient and long-term differential modulations of branched-chain α-keto acid decarboxylase activity in hypophysectomized rats

Stephen Gene Sullivan, Joseph Dancis, Rody P. Cox

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Hypophysectomy caused a marked but transient increase in branched-chain α-keto acid decarboxylase activities in rat liver mitochondria, peaking at about nine days post-surgery. The magnitude of increase is different for each of the three branched-chain α-keto acids. The activities then fall to a new steady state in three weeks with α-ketoisovalerate decarboxylase activity within the normal range, α-keto-β-methylvalerate decarboxylase activity at twice normal, and α-ketoisocaproate decarboxylase activity decreased to a level too low for accurate measurements.

Original languageEnglish (US)
Pages (from-to)135-141
Number of pages7
JournalBBA - General Subjects
Volume539
Issue number2
DOIs
StatePublished - Mar 1 1978

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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