Translocation (4;19)(q35;q13.1)-associated primitive round cell sarcoma: Report of a case and review of the literature

Dinesh Rakheja, Stanton Goldman, Kathleen S Wilson, Carl Lenarsky, Joel Weinthal, Roger A. Schuttz

Research output: Contribution to journalArticlepeer-review

29 Scopus citations

Abstract

We report the 4th case of a primitive round cell sarcoma with the translocation (4;19)(q35;q13.1) as the primary cytogenetic abnormality. This undifferentiated sarcoma shows some features of Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET), including a diffuse reactivity for FLI1, but it shows only focal and weak reactivity for CD99 and is negative for a rearrangement of EWS, the molecular signature of ES/ PNET. Recognition of the histopathologic and cytogenetic features of this entity is necessary to avoid its misdiagnosis as ES/PNET, especially in small biopsy samples.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalPediatric and Developmental Pathology
Volume11
Issue number3
DOIs
StatePublished - May 2008

Keywords

  • Cytogenetics
  • Ewing sarcoma
  • Primitive round cell sarcoma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pathology and Forensic Medicine

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