Transplantation of Olfactory Ensheathing Cells for Neural Repair

Zhida Su, Cheng He

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

As a unique type of glial cell in the olfactory system, olfactory ensheathing cells (OECs) are thought to be responsible for the successful regeneration of olfactory axons throughout the life of adult mammals. Because of their axonal growth-promoting properties, transplantation of OECs has been proposed as a promising experimental therapy for the treatment of neural injuries. Based on previous studies, several human clinical trials have been carried out to test the feasibility and safety of OEC transplantation for the treatment of central and peripheral nervous system lesions. This review provides an overview of the regeneration-promoting biological properties of OECs and of their therapeutic application in nervous system repair.

Original languageEnglish (US)
Title of host publicationNeural Regeneration
PublisherElsevier Inc.
Pages301-319
Number of pages19
ISBN (Print)9780128018347, 9780128017326
DOIs
StatePublished - Feb 6 2015

Keywords

  • Cell transplantation
  • Neural injury
  • Neural regeneration
  • Neural repair
  • Olfactory ensheathing cell

ASJC Scopus subject areas

  • Medicine(all)

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