Transposons, p53 and Genome Security

Bhavana Tiwari, Amanda E. Jones, John M. Abrams

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

p53, the most commonly mutated tumor suppressor, is a transcription factor known to regulate proliferation, senescence, and apoptosis. Compelling studies have found that p53 may prevent oncogenesis through effectors that are unrelated to these canonical processes and recent findings have uncovered ancient roles for p53 in the containment of mobile elements. Together, these developments raise the possibility that some p53-driven cancers could result from unrestrained transposons. Here, we explore evidence linking conserved features of p53 biology to the control of transposons. We also show how p53-deficient cells can be exploited to probe the behavior of transposons and illustrate how unrestrained transposons incited by p53 loss might contribute to human malignancies.

Original languageEnglish (US)
Pages (from-to)846-855
Number of pages10
JournalTrends in Genetics
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2018

Keywords

  • cancer
  • mobile elements
  • p53 biology
  • retrotransposons
  • transposons
  • transrepression

ASJC Scopus subject areas

  • Genetics

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