Abstract
From 1956 to 1972, 22 previously untreated patients with acromegaly received high dose (average equivalent dose 5700 rad in 5.66 weeks) megavohage (4-4.8 MeV) irradiation at Stanford, 3 post-operatively and 19 as the only intended treatment. Two patients required surgical intervention for deteriorating vision 3 months after initial treatment by irradiation alone, but received no additional treatment. Four patients (18.2%) have died 5-11 years after treatment, 2 of suicide and 2 of cerebrovascular accidents. Eight patients (36%) experienced improvement of their soft tissue acromegalic features whereas the remainder, including the 4 who died, had shown no progression of disease with follow-up ranging from 20 months to almost 18 years. Radiation-induced hormone deficiencies were limited to a need for thyroid in one of 11 patients initially euthyroid and a subsequent need for testosterone in 2 of 6 men approximately 4 years after treatment. Considerations in the treatment of patients with acromegaly and plans for a limited controlled study at Stanford are presented.
Original language | English (US) |
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Pages (from-to) | 885-893 |
Number of pages | 9 |
Journal | International journal of radiation oncology, biology, physics |
Volume | 1 |
Issue number | 9-10 |
DOIs | |
State | Published - 1976 |
Keywords
- Acromegaly
- Megavoltage irradiation
ASJC Scopus subject areas
- Radiation
- Oncology
- Radiology Nuclear Medicine and imaging
- Cancer Research