Treatment of Acute Diarrhea in Outpatients: Double-Blind Study Comparing Ampicillin and Placebo

K. C. Haltalin, H. T. Kusmiesz, L. V. Hinton, J. D. Nelson

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

A double-blind treatment study comparing ampicillin trihydrate and placebo was performed in 373 outpatients with acute diarrhea. No pathogens were isolated from 58.4% of patients. Shigella strains were recovered from 27.1% of patients, enteropathogenic serotypes of Escherichia coli were isolated from 9.1% of cases, and 3.2% of patients excreted Salmonella. Two pathogens were present in the stools of 2.1% of patients. Bacteriologic failure occurred in 8% of patients with shigellosis treated with ampicillin compared with a 70% failure rate in placebo-treated patients. Clinical failure developed in 5% of ampicillin-treated patients and in 40% of those who received placebo. Ampicillin is as effective in outpatients with milder shigellosis as it is in patients hospitalized with severe disease.

Original languageEnglish (US)
Pages (from-to)554-561
Number of pages8
JournalAmerican Journal of Diseases of Children
Volume124
Issue number4
DOIs
StatePublished - Oct 1972

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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