Treatment of Helicobacter pylori infection with omeprazole-amoxicillin combination therapy versus ranitidine/sodium bicarbonate-amoxicillin

M. T. Al-Assi, R. A. Cole, T. J. Karttunen, H. El-Zimaity, R. M. Genta, D. Y. Graham

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Objectives: Simpler, effective therapies to treat Helicobacter pylori infection are greatly needed. Omeprazole co-therapy apparently enhances effectiveness of some antimicrobials. Our objective in this study was to determine whether the apparent additional benefit provided by omeprazole to amoxicillin therapy could by equaled by a high dose of ranitidine plus sodium bicarbonate. Methods: In a prospective randomized trial, we tested 1 g amoxicillin b.i.d. with either omeprazole 20 mg b.i.d., or high dose ranitidine (900 and 1800 mg) plus sodium bicarbonate tablets 650 t.i.d. (with meals) for 14 day. Results: Fifty-two patients with documented H. pylori infection and peptic ulcer completed therapy. The cure rate with omeprazole and amoxicillin was poor (46%), with the 95% confidence interval (CI) = 25- 67%. Ranitidine plus sodium bicarbonate was also poor (39% cure) with the 95% CI = 21.5-59% (p > 0.57). Average compliance was more than 92% for all three groups. Side effects were experienced in only two patients (stomatitis and mild diarrhea). Conclusion: Neither the omeprazole nor ranitidine plus bicarbonate plus amoxicillin therapies used here can be recommended for treatment of H. pylori infection.

Original languageEnglish (US)
Pages (from-to)1411-1414
Number of pages4
JournalAmerican Journal of Gastroenterology
Volume90
Issue number9
StatePublished - 1995

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Sodium Bicarbonate
Ranitidine
Omeprazole
Amoxicillin
Helicobacter Infections
Helicobacter pylori
Therapeutics
Confidence Intervals
Stomatitis
Bicarbonates
Peptic Ulcer
Tablets
Compliance
Meals
Diarrhea

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Al-Assi, M. T., Cole, R. A., Karttunen, T. J., El-Zimaity, H., Genta, R. M., & Graham, D. Y. (1995). Treatment of Helicobacter pylori infection with omeprazole-amoxicillin combination therapy versus ranitidine/sodium bicarbonate-amoxicillin. American Journal of Gastroenterology, 90(9), 1411-1414.

Treatment of Helicobacter pylori infection with omeprazole-amoxicillin combination therapy versus ranitidine/sodium bicarbonate-amoxicillin. / Al-Assi, M. T.; Cole, R. A.; Karttunen, T. J.; El-Zimaity, H.; Genta, R. M.; Graham, D. Y.

In: American Journal of Gastroenterology, Vol. 90, No. 9, 1995, p. 1411-1414.

Research output: Contribution to journalArticle

Al-Assi, MT, Cole, RA, Karttunen, TJ, El-Zimaity, H, Genta, RM & Graham, DY 1995, 'Treatment of Helicobacter pylori infection with omeprazole-amoxicillin combination therapy versus ranitidine/sodium bicarbonate-amoxicillin', American Journal of Gastroenterology, vol. 90, no. 9, pp. 1411-1414.
Al-Assi, M. T. ; Cole, R. A. ; Karttunen, T. J. ; El-Zimaity, H. ; Genta, R. M. ; Graham, D. Y. / Treatment of Helicobacter pylori infection with omeprazole-amoxicillin combination therapy versus ranitidine/sodium bicarbonate-amoxicillin. In: American Journal of Gastroenterology. 1995 ; Vol. 90, No. 9. pp. 1411-1414.
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