Treatment of infants with malignant gliomas: The pediatric oncology group experience

Patricia K. Duffner, Jeffrey P. Krischer, Peter C. Burger, Michael E. Cohen, James W. Backstrom, Marc E. Horowitz, Robert A. Sanford, Henry S. Friedman, Larry E. Kun

Research output: Contribution to journalReview article

87 Citations (Scopus)

Abstract

Although survivals of infants with malignant brain tumors are worse than any other age group, one possible exception to this rule are the malignant gliomas. Eighteen children less than 3 years of age with malignant gliomas (glioblastoma multiforme, anaplastic astrocytoma and malignant glioma) were treated on the Pediatric Oncology Group regimen of prolonged postoperative chemotherapy and delayed irradiation, (1986-1990). Of 10 children evaluable for neuroradiologic response, 6 had partial responses (> 50% reduction) to two cycles of cyclophosphamide and vincristine. Progression free survivals at 1, 3 and 5 years were 54.25% ± 12, 43% ± 16 and 43% ± 23 respectively. Survivals at 5 years were 50% ± 14. Four children were not irradiated after 24 months of chemotherapy due to parental refusal and none have developed recurrent disease. Neither degree of surgical resection, presence or absence of metastases, nor pathology influenced survival but this may reflect small sample size. This study suggests that some malignant gliomas in infants are chemotherapy sensitive and may be associated with a good prognosis. Why infants with these high-grade gliomas fare better than adults is not clear. It is likely that there is something intrinsically different about them that cannot be identified on routine pathologic examination.

Original languageEnglish (US)
Pages (from-to)245-256
Number of pages12
JournalJournal of Neuro-Oncology
Volume28
Issue number2-3
StatePublished - Jul 5 1996

Fingerprint

Glioma
Pediatrics
Drug Therapy
Survival
Therapeutics
Astrocytoma
Vincristine
Glioblastoma
Brain Neoplasms
Sample Size
Cyclophosphamide
Disease-Free Survival
Age Groups
Pathology
Neoplasm Metastasis

Keywords

  • Chemotherapy
  • Infant brain tumors
  • Malignant gliomas

ASJC Scopus subject areas

  • Oncology
  • Neurology
  • Clinical Neurology
  • Cancer Research

Cite this

Duffner, P. K., Krischer, J. P., Burger, P. C., Cohen, M. E., Backstrom, J. W., Horowitz, M. E., ... Kun, L. E. (1996). Treatment of infants with malignant gliomas: The pediatric oncology group experience. Journal of Neuro-Oncology, 28(2-3), 245-256.

Treatment of infants with malignant gliomas : The pediatric oncology group experience. / Duffner, Patricia K.; Krischer, Jeffrey P.; Burger, Peter C.; Cohen, Michael E.; Backstrom, James W.; Horowitz, Marc E.; Sanford, Robert A.; Friedman, Henry S.; Kun, Larry E.

In: Journal of Neuro-Oncology, Vol. 28, No. 2-3, 05.07.1996, p. 245-256.

Research output: Contribution to journalReview article

Duffner, PK, Krischer, JP, Burger, PC, Cohen, ME, Backstrom, JW, Horowitz, ME, Sanford, RA, Friedman, HS & Kun, LE 1996, 'Treatment of infants with malignant gliomas: The pediatric oncology group experience', Journal of Neuro-Oncology, vol. 28, no. 2-3, pp. 245-256.
Duffner PK, Krischer JP, Burger PC, Cohen ME, Backstrom JW, Horowitz ME et al. Treatment of infants with malignant gliomas: The pediatric oncology group experience. Journal of Neuro-Oncology. 1996 Jul 5;28(2-3):245-256.
Duffner, Patricia K. ; Krischer, Jeffrey P. ; Burger, Peter C. ; Cohen, Michael E. ; Backstrom, James W. ; Horowitz, Marc E. ; Sanford, Robert A. ; Friedman, Henry S. ; Kun, Larry E. / Treatment of infants with malignant gliomas : The pediatric oncology group experience. In: Journal of Neuro-Oncology. 1996 ; Vol. 28, No. 2-3. pp. 245-256.
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