Treatment of syphilis in pregnancy and prevention of congenital syphilis

George D. Wendel, Jeanne S. Sheffield, Lisa M. Hollier, James B. Hill, Patrick S. Ramsey, Pablo J. Sánchez

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Studies about the management of syphilis during pregnancy were reviewed. They lacked uniformity in diagnostic criteria and study design. Currently recommended doses of benzathine penicillin G are effective in preventing congenital syphilis in most settings, although studies are needed regarding increased dosing regimens. Azithromycin and ceftriaxone offer potential alternatives for penicillin-allergic women, but insufficient data on efficacy limit their use in pregnancy. Ultrasonography provides a noninvasive means to examine pregnant women for signs of fetal syphilis, and abnormal findings indicate a risk for obstetric complications and fetal treatment failure. Ultrasonography should precede antepartum treatment during the latter half of pregnancy to gauge severity of fetal infection. However, optimal management of the affected fetus has not been established; collaborative management with a specialist is recommended. Antepartum screening remains a critical component of congenital syphilis prevention, even in the era of syphilis elimination.

Original languageEnglish (US)
JournalClinical Infectious Diseases
Volume35
Issue numberSUPPL. 2
DOIs
StatePublished - Oct 15 2002

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Congenital Syphilis
Syphilis
Pregnancy
Ultrasonography
Penicillin G Benzathine
Azithromycin
Ceftriaxone
Treatment Failure
Penicillins
Obstetrics
Pregnant Women
Fetus
Therapeutics
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Wendel, G. D., Sheffield, J. S., Hollier, L. M., Hill, J. B., Ramsey, P. S., & Sánchez, P. J. (2002). Treatment of syphilis in pregnancy and prevention of congenital syphilis. Clinical Infectious Diseases, 35(SUPPL. 2). https://doi.org/10.1086/342108

Treatment of syphilis in pregnancy and prevention of congenital syphilis. / Wendel, George D.; Sheffield, Jeanne S.; Hollier, Lisa M.; Hill, James B.; Ramsey, Patrick S.; Sánchez, Pablo J.

In: Clinical Infectious Diseases, Vol. 35, No. SUPPL. 2, 15.10.2002.

Research output: Contribution to journalArticle

Wendel, GD, Sheffield, JS, Hollier, LM, Hill, JB, Ramsey, PS & Sánchez, PJ 2002, 'Treatment of syphilis in pregnancy and prevention of congenital syphilis', Clinical Infectious Diseases, vol. 35, no. SUPPL. 2. https://doi.org/10.1086/342108
Wendel GD, Sheffield JS, Hollier LM, Hill JB, Ramsey PS, Sánchez PJ. Treatment of syphilis in pregnancy and prevention of congenital syphilis. Clinical Infectious Diseases. 2002 Oct 15;35(SUPPL. 2). https://doi.org/10.1086/342108
Wendel, George D. ; Sheffield, Jeanne S. ; Hollier, Lisa M. ; Hill, James B. ; Ramsey, Patrick S. ; Sánchez, Pablo J. / Treatment of syphilis in pregnancy and prevention of congenital syphilis. In: Clinical Infectious Diseases. 2002 ; Vol. 35, No. SUPPL. 2.
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