Abstract
OBJECTIVE: To evaluate the peer-reviewed literature that compares advanced venous leg ulcer therapies to standard of care with compression dressings. METHODS: A MEDLINE search for venous ulcer treatment with electrical stimulation, surgical vein correction, and bioengineered tissues was conducted. Randomized clinical trials comparing advanced treatment with standard of care using compression dressing were included. A total of 7 bioengineered tissue, 4 surgical treatment, and 4 electrical stimulation randomized clinical trials were identified. RESULTS: Compared with nonstandard treatments, electrical stimulation demonstrated improved wound healing, fewer adverse events, and shorter duration of healing. Healing rates at the end of the study were greater for surgical intervention, followed by similar outcomes for electrical stimulation and bioengineered tissues. Studies involving bioengineered tissues and surgical venous ablation demonstrated inconsistent/inconclusive results. CONCLUSIONS: Utilization of electrical stimulation in venous ulcer management has not been fully explored. Further studies of dosing electrical stimulation therapy may reveal therapeutic and preventive benefits for managing venous ulcers not yet elucidated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 164-172 |
| Number of pages | 9 |
| Journal | Advances in Skin and Wound Care |
| Volume | 28 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 27 2015 |
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Keywords
- Bioengineered tissue
- Edema
- Electrical stimulation
- Surgery
- Venous leg ulcer
- Wound healing
ASJC Scopus subject areas
- Advanced and Specialized Nursing
- Dermatology
Cite this
Treatment options for venous leg ulcers : Effectiveness of vascular surgery, bioengineered tissue, and electrical stimulation. / Thakral, Gaurav; La Fontaine, Javier; Kim, Paul; Najafi, Bijan; Nichols, Adam; Lavery, Lawrence A.
In: Advances in Skin and Wound Care, Vol. 28, No. 4, 27.04.2015, p. 164-172.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment options for venous leg ulcers
T2 - Effectiveness of vascular surgery, bioengineered tissue, and electrical stimulation
AU - Thakral, Gaurav
AU - La Fontaine, Javier
AU - Kim, Paul
AU - Najafi, Bijan
AU - Nichols, Adam
AU - Lavery, Lawrence A.
PY - 2015/4/27
Y1 - 2015/4/27
N2 - OBJECTIVE: To evaluate the peer-reviewed literature that compares advanced venous leg ulcer therapies to standard of care with compression dressings. METHODS: A MEDLINE search for venous ulcer treatment with electrical stimulation, surgical vein correction, and bioengineered tissues was conducted. Randomized clinical trials comparing advanced treatment with standard of care using compression dressing were included. A total of 7 bioengineered tissue, 4 surgical treatment, and 4 electrical stimulation randomized clinical trials were identified. RESULTS: Compared with nonstandard treatments, electrical stimulation demonstrated improved wound healing, fewer adverse events, and shorter duration of healing. Healing rates at the end of the study were greater for surgical intervention, followed by similar outcomes for electrical stimulation and bioengineered tissues. Studies involving bioengineered tissues and surgical venous ablation demonstrated inconsistent/inconclusive results. CONCLUSIONS: Utilization of electrical stimulation in venous ulcer management has not been fully explored. Further studies of dosing electrical stimulation therapy may reveal therapeutic and preventive benefits for managing venous ulcers not yet elucidated.
AB - OBJECTIVE: To evaluate the peer-reviewed literature that compares advanced venous leg ulcer therapies to standard of care with compression dressings. METHODS: A MEDLINE search for venous ulcer treatment with electrical stimulation, surgical vein correction, and bioengineered tissues was conducted. Randomized clinical trials comparing advanced treatment with standard of care using compression dressing were included. A total of 7 bioengineered tissue, 4 surgical treatment, and 4 electrical stimulation randomized clinical trials were identified. RESULTS: Compared with nonstandard treatments, electrical stimulation demonstrated improved wound healing, fewer adverse events, and shorter duration of healing. Healing rates at the end of the study were greater for surgical intervention, followed by similar outcomes for electrical stimulation and bioengineered tissues. Studies involving bioengineered tissues and surgical venous ablation demonstrated inconsistent/inconclusive results. CONCLUSIONS: Utilization of electrical stimulation in venous ulcer management has not been fully explored. Further studies of dosing electrical stimulation therapy may reveal therapeutic and preventive benefits for managing venous ulcers not yet elucidated.
KW - Bioengineered tissue
KW - Edema
KW - Electrical stimulation
KW - Surgery
KW - Venous leg ulcer
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=84925791363&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84925791363&partnerID=8YFLogxK
U2 - 10.1097/01.ASW.0000462328.60670.c3
DO - 10.1097/01.ASW.0000462328.60670.c3
M3 - Article
C2 - 25775200
AN - SCOPUS:84925791363
VL - 28
SP - 164
EP - 172
JO - Advances in Skin and Wound Care
JF - Advances in Skin and Wound Care
SN - 1527-7941
IS - 4
ER -