Triggers for genomic rearrangements: Insights into genomic, cellular and environmental influences

Ram Shankar Mani, Arul M. Chinnaiyan

Research output: Contribution to journalReview article

92 Scopus citations

Abstract

Genomic rearrangements are associated with many human genomic disorders, including cancers. It was previously thought that most genomic rearrangements formed randomly but emerging data suggest that many are nonrandom, cell type-, cell stage- and locus-specific events. Recent studies have revealed novel cellular mechanisms and environmental cues that influence genomic rearrangements. In this Review, we consider the multitude of influences on genomic rearrangements by grouping these influences into four categories: proximity of chromosomal regions in the nucleus, cellular stress, inappropriate DNA repair or recombination, and DNA sequence and chromatin features. The synergy of these triggers can poise a cell for rearrangements and here we aim to provide a conceptual framework for understanding the genesis of genomic rearrangements.

Original languageEnglish (US)
Pages (from-to)819-829
Number of pages11
JournalNature Reviews Genetics
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2010

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Genetics(clinical)

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