Troponin and cardiomyopathy

Audrey N. Chang, Michelle S. Parvatiyar, James D. Potter

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The troponin complex was discovered over thirty years ago and since then much insight has been gained into how this complex senses fluctuating levels of Ca2+ and transmits this signal to the myofilament. Advances in genetics methods have allowed identification of mutations that lead to the phenotypically distinct cardiomyopathies: hypertrophic cardiomyopathy (HCM), restrictive cardiomyopathy (RCM) and dilated cardiomyopathy (DCM). This review serves to highlight key in vivo studies of mutation effects that have followed many years of functional studies and discusses how these mutations alter energetics and promote the characteristic remodeling associated with cardiomyopathic diseases. Studies have been performed that examine alterations in signaling and genomic methods have been employed to isolate upregulated proteins, however these processes are complex as there are multiple roads to hypertrophy or dilation associated with genetic cardiomyopathies. This review suggests future directions to explore in the troponin field that would heighten our understanding of the complex regulation of cardiac muscle contraction.

Original languageEnglish (US)
Pages (from-to)74-81
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume369
Issue number1
DOIs
StatePublished - Apr 25 2008

Keywords

  • HCM
  • In vivo studies
  • RCM and DCM cardiomyopathies
  • Troponin

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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