Tumor alignment between 4DCT and 4D cone beam CT for Irregular respiratory patient - A phantom study

C. Ding, L. Huang, L. Papiez, R. Timmerman, T. Solberg

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The purpose of this study is to compare the lung tumor characteristics on Four-Dimensional Cone Beam Computed Tomography (4DCBCT), used for daily patient localization, with Four-Dimensional Computed Tomography (4DCT) used in treatment planning. A programmable motion phantom was used to simulate patients' respiratory motion and loalization based on both 4DCT and 4DCBCT. Two motion patterns, one a regular sinusoidal motion and the other an irregular pattern, were included in the study. The regular motion pattern represented a perfectly sinusoidal respiratory motion with amplitude of 14.5 mm. The irregular motion pattern, which was collected from a real patient, had average target motion amplitude of 15.2 mm with the minimum and maximum motion amplitude of 6.7 mm and 21.5 mm respectively. Our results for regular sinusoidal motion suggest that the 4DCT and 4DCBCT can be appropriately aligned on each individual respiratory phase or on MIP images. The error of alignment is less than 1mm. For irregular respiratory motion, both modalities underestimate tumor motion. In this case 4DCBCT provided a better representation of temporal target shape than 4DCT. There was a difference in location of the target centroid motion between both modalities due to image distortion cause by irregular motion (1.4 mm and 2.8 mm for block and cylinder target objects respectively). We concluded that 4DCT and 4DCBCT can be used to provide good patient alignment with regular breathing. However, the use of MIP and/or end exhalation phase images improves localization in those patients exhibiting irregular breathing pattern. Additionally, methods which can improve regularity of breathing (e.g., audio or visual coaching) should be considered for these patients.

Original languageEnglish (US)
Title of host publicationIFMBE Proceedings
Pages515-518
Number of pages4
Volume25
Edition1
DOIs
StatePublished - 2009
EventWorld Congress on Medical Physics and Biomedical Engineering: Radiation Oncology - Munich, Germany
Duration: Sep 7 2009Sep 12 2009

Other

OtherWorld Congress on Medical Physics and Biomedical Engineering: Radiation Oncology
CountryGermany
CityMunich
Period9/7/099/12/09

Fingerprint

Tomography
Cones
Tumors
Planning

Keywords

  • 4DCBCT
  • 4DCT
  • MIP
  • Respiratory motion
  • SBRT

ASJC Scopus subject areas

  • Biomedical Engineering
  • Bioengineering

Cite this

Tumor alignment between 4DCT and 4D cone beam CT for Irregular respiratory patient - A phantom study. / Ding, C.; Huang, L.; Papiez, L.; Timmerman, R.; Solberg, T.

IFMBE Proceedings. Vol. 25 1. ed. 2009. p. 515-518.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ding, C, Huang, L, Papiez, L, Timmerman, R & Solberg, T 2009, Tumor alignment between 4DCT and 4D cone beam CT for Irregular respiratory patient - A phantom study. in IFMBE Proceedings. 1 edn, vol. 25, pp. 515-518, World Congress on Medical Physics and Biomedical Engineering: Radiation Oncology, Munich, Germany, 9/7/09. https://doi.org/10.1007/978-3-642-03474-9-144
Ding, C. ; Huang, L. ; Papiez, L. ; Timmerman, R. ; Solberg, T. / Tumor alignment between 4DCT and 4D cone beam CT for Irregular respiratory patient - A phantom study. IFMBE Proceedings. Vol. 25 1. ed. 2009. pp. 515-518
@inproceedings{30449401db07410b82911e9f3a2ead0d,
title = "Tumor alignment between 4DCT and 4D cone beam CT for Irregular respiratory patient - A phantom study",
abstract = "The purpose of this study is to compare the lung tumor characteristics on Four-Dimensional Cone Beam Computed Tomography (4DCBCT), used for daily patient localization, with Four-Dimensional Computed Tomography (4DCT) used in treatment planning. A programmable motion phantom was used to simulate patients' respiratory motion and loalization based on both 4DCT and 4DCBCT. Two motion patterns, one a regular sinusoidal motion and the other an irregular pattern, were included in the study. The regular motion pattern represented a perfectly sinusoidal respiratory motion with amplitude of 14.5 mm. The irregular motion pattern, which was collected from a real patient, had average target motion amplitude of 15.2 mm with the minimum and maximum motion amplitude of 6.7 mm and 21.5 mm respectively. Our results for regular sinusoidal motion suggest that the 4DCT and 4DCBCT can be appropriately aligned on each individual respiratory phase or on MIP images. The error of alignment is less than 1mm. For irregular respiratory motion, both modalities underestimate tumor motion. In this case 4DCBCT provided a better representation of temporal target shape than 4DCT. There was a difference in location of the target centroid motion between both modalities due to image distortion cause by irregular motion (1.4 mm and 2.8 mm for block and cylinder target objects respectively). We concluded that 4DCT and 4DCBCT can be used to provide good patient alignment with regular breathing. However, the use of MIP and/or end exhalation phase images improves localization in those patients exhibiting irregular breathing pattern. Additionally, methods which can improve regularity of breathing (e.g., audio or visual coaching) should be considered for these patients.",
keywords = "4DCBCT, 4DCT, MIP, Respiratory motion, SBRT",
author = "C. Ding and L. Huang and L. Papiez and R. Timmerman and T. Solberg",
year = "2009",
doi = "10.1007/978-3-642-03474-9-144",
language = "English (US)",
isbn = "9783642034725",
volume = "25",
pages = "515--518",
booktitle = "IFMBE Proceedings",
edition = "1",

}

TY - GEN

T1 - Tumor alignment between 4DCT and 4D cone beam CT for Irregular respiratory patient - A phantom study

AU - Ding, C.

AU - Huang, L.

AU - Papiez, L.

AU - Timmerman, R.

AU - Solberg, T.

PY - 2009

Y1 - 2009

N2 - The purpose of this study is to compare the lung tumor characteristics on Four-Dimensional Cone Beam Computed Tomography (4DCBCT), used for daily patient localization, with Four-Dimensional Computed Tomography (4DCT) used in treatment planning. A programmable motion phantom was used to simulate patients' respiratory motion and loalization based on both 4DCT and 4DCBCT. Two motion patterns, one a regular sinusoidal motion and the other an irregular pattern, were included in the study. The regular motion pattern represented a perfectly sinusoidal respiratory motion with amplitude of 14.5 mm. The irregular motion pattern, which was collected from a real patient, had average target motion amplitude of 15.2 mm with the minimum and maximum motion amplitude of 6.7 mm and 21.5 mm respectively. Our results for regular sinusoidal motion suggest that the 4DCT and 4DCBCT can be appropriately aligned on each individual respiratory phase or on MIP images. The error of alignment is less than 1mm. For irregular respiratory motion, both modalities underestimate tumor motion. In this case 4DCBCT provided a better representation of temporal target shape than 4DCT. There was a difference in location of the target centroid motion between both modalities due to image distortion cause by irregular motion (1.4 mm and 2.8 mm for block and cylinder target objects respectively). We concluded that 4DCT and 4DCBCT can be used to provide good patient alignment with regular breathing. However, the use of MIP and/or end exhalation phase images improves localization in those patients exhibiting irregular breathing pattern. Additionally, methods which can improve regularity of breathing (e.g., audio or visual coaching) should be considered for these patients.

AB - The purpose of this study is to compare the lung tumor characteristics on Four-Dimensional Cone Beam Computed Tomography (4DCBCT), used for daily patient localization, with Four-Dimensional Computed Tomography (4DCT) used in treatment planning. A programmable motion phantom was used to simulate patients' respiratory motion and loalization based on both 4DCT and 4DCBCT. Two motion patterns, one a regular sinusoidal motion and the other an irregular pattern, were included in the study. The regular motion pattern represented a perfectly sinusoidal respiratory motion with amplitude of 14.5 mm. The irregular motion pattern, which was collected from a real patient, had average target motion amplitude of 15.2 mm with the minimum and maximum motion amplitude of 6.7 mm and 21.5 mm respectively. Our results for regular sinusoidal motion suggest that the 4DCT and 4DCBCT can be appropriately aligned on each individual respiratory phase or on MIP images. The error of alignment is less than 1mm. For irregular respiratory motion, both modalities underestimate tumor motion. In this case 4DCBCT provided a better representation of temporal target shape than 4DCT. There was a difference in location of the target centroid motion between both modalities due to image distortion cause by irregular motion (1.4 mm and 2.8 mm for block and cylinder target objects respectively). We concluded that 4DCT and 4DCBCT can be used to provide good patient alignment with regular breathing. However, the use of MIP and/or end exhalation phase images improves localization in those patients exhibiting irregular breathing pattern. Additionally, methods which can improve regularity of breathing (e.g., audio or visual coaching) should be considered for these patients.

KW - 4DCBCT

KW - 4DCT

KW - MIP

KW - Respiratory motion

KW - SBRT

UR - http://www.scopus.com/inward/record.url?scp=77950446122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950446122&partnerID=8YFLogxK

U2 - 10.1007/978-3-642-03474-9-144

DO - 10.1007/978-3-642-03474-9-144

M3 - Conference contribution

AN - SCOPUS:77950446122

SN - 9783642034725

VL - 25

SP - 515

EP - 518

BT - IFMBE Proceedings

ER -