Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature

Research output: Contribution to journalArticle

428 Scopus citations

Abstract

Selective occlusion of tumor vasculature was tested as a therapy for solid tumors in a mouse model. The formation of blood clots (thrombosis) within the tumor vessels was initiated by targeting the cell surface domain of human tissue factor, by means of a bispecific antibody, to an experimentally induced marker on tumor vascular endothelial cells. This truncated form of tissue factor (tTF) had limited ability to initiate thrombosis when free in the circulation, but became an effective and selective thrombogen when targeted to tumor endothelial cells. Intravenous administration of the antibody-tTF complex to mice with large neuroblastomas resulted in complete tumor regressions in 38 percent of the mice.

Original languageEnglish (US)
Pages (from-to)547-550
Number of pages4
JournalScience
Volume275
Issue number5299
DOIs
Publication statusPublished - Jan 24 1997

    Fingerprint

ASJC Scopus subject areas

  • General

Cite this

Huang, X., Molema, G., King, S., Watkins, L., Edgington, T. S., & Thorpe, P. E. (1997). Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science, 275(5299), 547-550. https://doi.org/10.1126/science.275.5299.547