TY - JOUR
T1 - Tumor necrosis on magnetic resonance imaging correlates with aggressive histology and disease progression in clear cell renal cell carcinoma
AU - Beddy, Peter
AU - Genega, Elizabeth M.
AU - Ngo, Long
AU - Hindman, Nicole
AU - Wei, Jesse
AU - Bullock, Andrea
AU - Bhatt, Rupal S.
AU - Atkins, Michael B.
AU - Pedrosa, Ivan
N1 - Funding Information:
Funding: This work was conducted with support from the Harvard Catalyst/The Harvard Clinical and Translational Science Center (National Institutes of Health Award #UL1 RR 025758 and financial contributions from Harvard University and its affiliated academic health care centers). The content is solely the responsibility of the authors and does not necessarily represent the official views of Harvard Catalyst, Harvard University, and its affiliated academic health care centers, the National Center for Research Resources, or the National Institutes of Health. The authors have stated that they have no conflicts of interest.
PY - 2014/2
Y1 - 2014/2
N2 - Objective The study objective was to correlate the magnetic resonance imaging (MRI) features of clear cell renal cell carcinoma (ccRCC) with the histopathologic features and disease progression. Methods Institutional review board approval for this retrospective study was obtained; patient consent was not required. The initial staging MRI scans of 75 patients with histologically confirmed ccRCC were retrospectively reviewed. The imaging was assessed by 2 radiologists for the presence of tumor necrosis, cystic degeneration, intracellular fat, hemorrhage, retroperitoneal collaterals, and renal vein thrombosis. Quantitative analysis for the MRI presence of intracellular lipid within tumors was performed. MRI findings were correlated with histopathologic findings of clear cell percentage, alveolar and tubular growth pattern, and disease progression. Statistical associations were evaluated with nonparametric univariable analyses and multivariable logistic regression models. Results Correlation between MRI and histopathologic features was performed in 75 patients, whereas follow-up data were available for progression analysis in 68 patients. The presence of tumor necrosis, retroperitoneal collaterals, and renal vein thrombosis on MRI was significantly associated with a low percentage of tumor cells with clear cytoplasm (P <.01) and metastatic disease at presentation or disease progression (P <.01). At multivariable analysis, necrosis remained the only feature statistically associated with disease progression (P =.03; adjusted odds ratio, 27.7; 95% confidence interval, 1.4-554.7 for reader 1 and P =.02; adjusted odds ratio, 29.3; 95% confidence interval, 1.7-520.8 for reader 2). Conclusions Necrosis in ccRCC on MRI correlates with the histopathologic finding of lower percentage of tumor cells with clear cytoplasm and is a poor prognostic indicator irrespective of tumor size.
AB - Objective The study objective was to correlate the magnetic resonance imaging (MRI) features of clear cell renal cell carcinoma (ccRCC) with the histopathologic features and disease progression. Methods Institutional review board approval for this retrospective study was obtained; patient consent was not required. The initial staging MRI scans of 75 patients with histologically confirmed ccRCC were retrospectively reviewed. The imaging was assessed by 2 radiologists for the presence of tumor necrosis, cystic degeneration, intracellular fat, hemorrhage, retroperitoneal collaterals, and renal vein thrombosis. Quantitative analysis for the MRI presence of intracellular lipid within tumors was performed. MRI findings were correlated with histopathologic findings of clear cell percentage, alveolar and tubular growth pattern, and disease progression. Statistical associations were evaluated with nonparametric univariable analyses and multivariable logistic regression models. Results Correlation between MRI and histopathologic features was performed in 75 patients, whereas follow-up data were available for progression analysis in 68 patients. The presence of tumor necrosis, retroperitoneal collaterals, and renal vein thrombosis on MRI was significantly associated with a low percentage of tumor cells with clear cytoplasm (P <.01) and metastatic disease at presentation or disease progression (P <.01). At multivariable analysis, necrosis remained the only feature statistically associated with disease progression (P =.03; adjusted odds ratio, 27.7; 95% confidence interval, 1.4-554.7 for reader 1 and P =.02; adjusted odds ratio, 29.3; 95% confidence interval, 1.7-520.8 for reader 2). Conclusions Necrosis in ccRCC on MRI correlates with the histopathologic finding of lower percentage of tumor cells with clear cytoplasm and is a poor prognostic indicator irrespective of tumor size.
KW - MRI
KW - carcinoma
KW - clear cell metastatic renal cell carcinoma
KW - clear cell percentage
KW - kidney neoplasms
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U2 - 10.1016/j.clgc.2013.07.006
DO - 10.1016/j.clgc.2013.07.006
M3 - Article
C2 - 24145001
AN - SCOPUS:84892435018
SN - 1558-7673
VL - 12
SP - 55
EP - 62
JO - Clinical Genitourinary Cancer
JF - Clinical Genitourinary Cancer
IS - 1
ER -