Tumor progression following petroclival meningioma subtotal resection: A volumetric study

Jacob B. Hunter, Brendan P. O'Connell, Matthew L. Carlson, Lola C. Chambless, Robert J. Yawn, Ray Wang, Akshitkumar Mistry, Reid C. Thompson, Kyle D.Weaver, George B. Wanna

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: One study has investigated postoperative growth rates following subtotal resection of petroclival meningiomas utilizing linear measurements, which are insensitive to the multidimensional complex growth of meningiomas, to estimate tumor volume. OBJECTIVE: To describe petroclival meningioma growth patterns following less-thancomplete resection utilizing volumetric analysis and to identify variables associated with tumor progression. METHODS: Patients with surgically resected WHO grade I petroclival meningiomas were retrospectively reviewed (1999-2015). Image analysis software was utilized to perform volumetric analyses of tumor size and growth on serial MRI studies. The impact of preoperative and postoperative variables on tumor growth after subtotal resection was analyzed. An increase in tumor volume of at least 20% was defined as "tumor growth." RESULTS: Twenty-three patients had immediate preoperative and serial postoperativeMRI studies available for review. Themean preoperative tumor volumewas 20.9cm3 (range 0.4- 54.6). The mean extent of resection was 75.5% (range 31.5%-100.0%). At a mean follow-up of 24.8 mo, 12 tumors (66.7%) exhibited radiological tumor growth, while 6 tumors did not change in size. The median annual volumetric growth rate was 2.82 cm3/yr (range -0.34 to 10.1). Extent of resection and immediate postoperative tumor volume were significantly correlated with the annual volumetric growth rate following resection. At last follow-up, 3 (13%) patients required further intervention. CONCLUSION: Themajority of petroclival meningiomas exhibit growth following subtotal resection. Extent of resection is strongly associated with risk for disease progression following surgery.

Original languageEnglish (US)
Pages (from-to)215-223
Number of pages9
JournalOperative Neurosurgery
Volume14
Issue number3
DOIs
StatePublished - Mar 1 2018

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Meningioma
Growth
Neoplasms
Tumor Burden
Disease Progression
Software

Keywords

  • Meningioma
  • Petroclival meningioma
  • Skull base subtotal resection
  • Volumetric growth

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Hunter, J. B., O'Connell, B. P., Carlson, M. L., Chambless, L. C., Yawn, R. J., Wang, R., ... Wanna, G. B. (2018). Tumor progression following petroclival meningioma subtotal resection: A volumetric study. Operative Neurosurgery, 14(3), 215-223. https://doi.org/10.1093/ons/opx098

Tumor progression following petroclival meningioma subtotal resection : A volumetric study. / Hunter, Jacob B.; O'Connell, Brendan P.; Carlson, Matthew L.; Chambless, Lola C.; Yawn, Robert J.; Wang, Ray; Mistry, Akshitkumar; Thompson, Reid C.; D.Weaver, Kyle; Wanna, George B.

In: Operative Neurosurgery, Vol. 14, No. 3, 01.03.2018, p. 215-223.

Research output: Contribution to journalArticle

Hunter, JB, O'Connell, BP, Carlson, ML, Chambless, LC, Yawn, RJ, Wang, R, Mistry, A, Thompson, RC, D.Weaver, K & Wanna, GB 2018, 'Tumor progression following petroclival meningioma subtotal resection: A volumetric study', Operative Neurosurgery, vol. 14, no. 3, pp. 215-223. https://doi.org/10.1093/ons/opx098
Hunter, Jacob B. ; O'Connell, Brendan P. ; Carlson, Matthew L. ; Chambless, Lola C. ; Yawn, Robert J. ; Wang, Ray ; Mistry, Akshitkumar ; Thompson, Reid C. ; D.Weaver, Kyle ; Wanna, George B. / Tumor progression following petroclival meningioma subtotal resection : A volumetric study. In: Operative Neurosurgery. 2018 ; Vol. 14, No. 3. pp. 215-223.
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abstract = "BACKGROUND: One study has investigated postoperative growth rates following subtotal resection of petroclival meningiomas utilizing linear measurements, which are insensitive to the multidimensional complex growth of meningiomas, to estimate tumor volume. OBJECTIVE: To describe petroclival meningioma growth patterns following less-thancomplete resection utilizing volumetric analysis and to identify variables associated with tumor progression. METHODS: Patients with surgically resected WHO grade I petroclival meningiomas were retrospectively reviewed (1999-2015). Image analysis software was utilized to perform volumetric analyses of tumor size and growth on serial MRI studies. The impact of preoperative and postoperative variables on tumor growth after subtotal resection was analyzed. An increase in tumor volume of at least 20{\%} was defined as {"}tumor growth.{"} RESULTS: Twenty-three patients had immediate preoperative and serial postoperativeMRI studies available for review. Themean preoperative tumor volumewas 20.9cm3 (range 0.4- 54.6). The mean extent of resection was 75.5{\%} (range 31.5{\%}-100.0{\%}). At a mean follow-up of 24.8 mo, 12 tumors (66.7{\%}) exhibited radiological tumor growth, while 6 tumors did not change in size. The median annual volumetric growth rate was 2.82 cm3/yr (range -0.34 to 10.1). Extent of resection and immediate postoperative tumor volume were significantly correlated with the annual volumetric growth rate following resection. At last follow-up, 3 (13{\%}) patients required further intervention. CONCLUSION: Themajority of petroclival meningiomas exhibit growth following subtotal resection. Extent of resection is strongly associated with risk for disease progression following surgery.",
keywords = "Meningioma, Petroclival meningioma, Skull base subtotal resection, Volumetric growth",
author = "Hunter, {Jacob B.} and O'Connell, {Brendan P.} and Carlson, {Matthew L.} and Chambless, {Lola C.} and Yawn, {Robert J.} and Ray Wang and Akshitkumar Mistry and Thompson, {Reid C.} and Kyle D.Weaver and Wanna, {George B.}",
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T1 - Tumor progression following petroclival meningioma subtotal resection

T2 - A volumetric study

AU - Hunter, Jacob B.

AU - O'Connell, Brendan P.

AU - Carlson, Matthew L.

AU - Chambless, Lola C.

AU - Yawn, Robert J.

AU - Wang, Ray

AU - Mistry, Akshitkumar

AU - Thompson, Reid C.

AU - D.Weaver, Kyle

AU - Wanna, George B.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - BACKGROUND: One study has investigated postoperative growth rates following subtotal resection of petroclival meningiomas utilizing linear measurements, which are insensitive to the multidimensional complex growth of meningiomas, to estimate tumor volume. OBJECTIVE: To describe petroclival meningioma growth patterns following less-thancomplete resection utilizing volumetric analysis and to identify variables associated with tumor progression. METHODS: Patients with surgically resected WHO grade I petroclival meningiomas were retrospectively reviewed (1999-2015). Image analysis software was utilized to perform volumetric analyses of tumor size and growth on serial MRI studies. The impact of preoperative and postoperative variables on tumor growth after subtotal resection was analyzed. An increase in tumor volume of at least 20% was defined as "tumor growth." RESULTS: Twenty-three patients had immediate preoperative and serial postoperativeMRI studies available for review. Themean preoperative tumor volumewas 20.9cm3 (range 0.4- 54.6). The mean extent of resection was 75.5% (range 31.5%-100.0%). At a mean follow-up of 24.8 mo, 12 tumors (66.7%) exhibited radiological tumor growth, while 6 tumors did not change in size. The median annual volumetric growth rate was 2.82 cm3/yr (range -0.34 to 10.1). Extent of resection and immediate postoperative tumor volume were significantly correlated with the annual volumetric growth rate following resection. At last follow-up, 3 (13%) patients required further intervention. CONCLUSION: Themajority of petroclival meningiomas exhibit growth following subtotal resection. Extent of resection is strongly associated with risk for disease progression following surgery.

AB - BACKGROUND: One study has investigated postoperative growth rates following subtotal resection of petroclival meningiomas utilizing linear measurements, which are insensitive to the multidimensional complex growth of meningiomas, to estimate tumor volume. OBJECTIVE: To describe petroclival meningioma growth patterns following less-thancomplete resection utilizing volumetric analysis and to identify variables associated with tumor progression. METHODS: Patients with surgically resected WHO grade I petroclival meningiomas were retrospectively reviewed (1999-2015). Image analysis software was utilized to perform volumetric analyses of tumor size and growth on serial MRI studies. The impact of preoperative and postoperative variables on tumor growth after subtotal resection was analyzed. An increase in tumor volume of at least 20% was defined as "tumor growth." RESULTS: Twenty-three patients had immediate preoperative and serial postoperativeMRI studies available for review. Themean preoperative tumor volumewas 20.9cm3 (range 0.4- 54.6). The mean extent of resection was 75.5% (range 31.5%-100.0%). At a mean follow-up of 24.8 mo, 12 tumors (66.7%) exhibited radiological tumor growth, while 6 tumors did not change in size. The median annual volumetric growth rate was 2.82 cm3/yr (range -0.34 to 10.1). Extent of resection and immediate postoperative tumor volume were significantly correlated with the annual volumetric growth rate following resection. At last follow-up, 3 (13%) patients required further intervention. CONCLUSION: Themajority of petroclival meningiomas exhibit growth following subtotal resection. Extent of resection is strongly associated with risk for disease progression following surgery.

KW - Meningioma

KW - Petroclival meningioma

KW - Skull base subtotal resection

KW - Volumetric growth

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DO - 10.1093/ons/opx098

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