Tumor suppression by chromosome 11 is not due to cellular senescence

Yi Ning, Jerry W. Shay, Mercedes Lovell, Linda Taylor, David H. Ledbetter, Olivia M. Pereira-Smith

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Abstract

Previous hybrid studies involving fusion of normal with immortal human cells indicated that the phenotype of cellular senescence is dominant and that immortality results from recessive changes in normal growth regulatory genes. We have further assigned 28 different immortal human cell lines to at least four complementation groups for indefinite division. In order to identify the chromosomes involved in regulating cell proliferation, we have introduced single human chromosomes by microcell fusion into immortal human cells representative of the different complementation groups. Our results demonstrate that the introduction of chromosome 11, implicated in tumor suppression, does not cause cellular senescence in three different immortal human cell lines tested.

Original languageEnglish (US)
Pages (from-to)220-226
Number of pages7
JournalExperimental Cell Research
Volume192
Issue number1
DOIs
StatePublished - Jan 1991

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ASJC Scopus subject areas

  • Cell Biology

Cite this

Ning, Y., Shay, J. W., Lovell, M., Taylor, L., Ledbetter, D. H., & Pereira-Smith, O. M. (1991). Tumor suppression by chromosome 11 is not due to cellular senescence. Experimental Cell Research, 192(1), 220-226. https://doi.org/10.1016/0014-4827(91)90179-X