The addition of a 7-hydroxyl group is an early and often rate-limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7α-hydroxylase and oxysterol 7α-hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7α-hydroxylated bile acids.
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)