Abstract
The addition of a 7-hydroxyl group is an early and often rate-limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7α-hydroxylase and oxysterol 7α-hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7α-hydroxylated bile acids.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 113-118 |
| Number of pages | 6 |
| Journal | Current opinion in lipidology |
| Volume | 9 |
| Issue number | 2 |
| DOIs | |
| State | Published - 1998 |
ASJC Scopus subject areas
- Endocrinology, Diabetes and Metabolism
- Molecular Biology
- Genetics
- Nutrition and Dietetics
- Cardiology and Cardiovascular Medicine
- Cell Biology