Two 7α-hydroxylase enzymes in bile acid biosynthesis

Margrit Schwarz, Erik G. Lund, David W. Russell

Research output: Contribution to journalArticle

82 Scopus citations


The addition of a 7-hydroxyl group is an early and often rate-limiting step in the synthesis of bile acids. This reaction is catalysed by two cytochrome P450 enzymes known as cholesterol 7α-hydroxylase and oxysterol 7α-hydroxylase. cDNAs encoding these proteins have been isolated and used to define two evolutionarily conserved pathways that produce 7α-hydroxylated bile acids.

Original languageEnglish (US)
Pages (from-to)113-118
Number of pages6
JournalCurrent Opinion in Lipidology
Issue number2
Publication statusPublished - 1998


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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