Two birds, one stone: Non-canonical therapeutic effects of the PARP inhibitor Talazoparib

Sridevi Challa; W. Lee Kraus

doi:10.1016/j.chembiol.2022.02.002

Two birds, one stone: Non-canonical therapeutic effects of the PARP inhibitor Talazoparib

Sridevi Challa, W. Lee Kraus

Research output: Contribution to journal › Comment/debate › peer-review

2 Scopus citations

Abstract

In this issue of Cell Chemical Biology, Palve et al. (2022) identified PARP16 as a non-canonical therapeutic target of the PARP1 inhibitor talazoparib, which synergizes with the WEE1 inhibitor adavosertib to enhance its efficacy. The dual targeting of PARP1 and PARP16 may explain the greater efficacy of talazoparib in some cancers.

Original language	English (US)
Pages (from-to)	171-173
Number of pages	3
Journal	Cell Chemical Biology
Volume	29
Issue number	2
DOIs	https://doi.org/10.1016/j.chembiol.2022.02.002
State	Published - Feb 17 2022

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2022.02.002

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abstract = "In this issue of Cell Chemical Biology, Palve et al. (2022) identified PARP16 as a non-canonical therapeutic target of the PARP1 inhibitor talazoparib, which synergizes with the WEE1 inhibitor adavosertib to enhance its efficacy. The dual targeting of PARP1 and PARP16 may explain the greater efficacy of talazoparib in some cancers.",

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Two birds, one stone: Non-canonical therapeutic effects of the PARP inhibitor Talazoparib

Abstract

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