Type I interferons and T helper development

J. David Farrar, Kenneth M. Murphy

Research output: Contribution to journalArticle

90 Scopus citations

Abstract

Type I interferons (IFN-1s) activate Stat4 and promote Th1 development in human, but not mouse, CD4+ T cells. Recently, IFN-1-induced Stat4 activation in human cells was found to require interactions of Stat4 with Stat2. A remarkable genetic dissimilarity between murine and human Stat2 explains the ability of human, but not mouse, CD4+ T cells to undergo IFN-1-induced Stat4 activation and Th1 development.

Original languageEnglish (US)
Pages (from-to)484-489
Number of pages6
JournalImmunology Today
Volume21
Issue number10
DOIs
Publication statusPublished - 2000

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ASJC Scopus subject areas

  • Immunology

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