Type III Effector VopC Mediates Invasion for Vibrio Species

Lingling Zhang, Anne Marie Krachler, Christopher A. Broberg, Yan Li, Hamid Mirzael, Christopher J. Gilpin, Kim Orth

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Vibrio spp. are associated with infections caused by contaminated food and water. A type III secretion system (T3SS2) is a shared feature of all clinical isolates of . V. parahaemolyticus and some . V. cholerae strains. Despite its being responsible for enterotoxicity, no molecular mechanism has been determined for the T3SS2-dependent pathogenicity. Here, we show that although . Vibrio spp. are typically thought of as extracellular pathogens, the T3SS2 of . Vibrio mediates host cell invasion, vacuole formation, and replication of intracellular bacteria. The catalytically active effector VopC is critical for . Vibrio T3SS2-mediated invasion. There are other marine bacteria encoding VopC homologs associated with a T3SS; therefore, we predict that these bacteria are also likely to use T3SS-mediated invasion as part of their pathogenesis mechanisms. These findings suggest a new molecular paradigm for . Vibrio pathogenicity and modify our view of the roles of T3SS effectors that are translocated during infection.

Original languageEnglish (US)
Pages (from-to)453-460
Number of pages8
JournalCell Reports
Volume1
Issue number5
DOIs
StatePublished - May 31 2012

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Vibrio
Bacteria
Pathogens
Virulence
Cholera
Vacuoles
Infection
Water
Food

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Zhang, L., Krachler, A. M., Broberg, C. A., Li, Y., Mirzael, H., Gilpin, C. J., & Orth, K. (2012). Type III Effector VopC Mediates Invasion for Vibrio Species. Cell Reports, 1(5), 453-460. https://doi.org/10.1016/j.celrep.2012.04.004

Type III Effector VopC Mediates Invasion for Vibrio Species. / Zhang, Lingling; Krachler, Anne Marie; Broberg, Christopher A.; Li, Yan; Mirzael, Hamid; Gilpin, Christopher J.; Orth, Kim.

In: Cell Reports, Vol. 1, No. 5, 31.05.2012, p. 453-460.

Research output: Contribution to journalArticle

Zhang, L, Krachler, AM, Broberg, CA, Li, Y, Mirzael, H, Gilpin, CJ & Orth, K 2012, 'Type III Effector VopC Mediates Invasion for Vibrio Species', Cell Reports, vol. 1, no. 5, pp. 453-460. https://doi.org/10.1016/j.celrep.2012.04.004
Zhang L, Krachler AM, Broberg CA, Li Y, Mirzael H, Gilpin CJ et al. Type III Effector VopC Mediates Invasion for Vibrio Species. Cell Reports. 2012 May 31;1(5):453-460. https://doi.org/10.1016/j.celrep.2012.04.004
Zhang, Lingling ; Krachler, Anne Marie ; Broberg, Christopher A. ; Li, Yan ; Mirzael, Hamid ; Gilpin, Christopher J. ; Orth, Kim. / Type III Effector VopC Mediates Invasion for Vibrio Species. In: Cell Reports. 2012 ; Vol. 1, No. 5. pp. 453-460.
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