Type-specific regulation of adenylyl cyclase by G protein βγ subunits

Wei Jen Tang, Alfred G. Gilman

Research output: Contribution to journalArticle

716 Citations (Scopus)

Abstract

Heterotrimeric guanine nucleotide-binding regulatory proteins (G proteins) dissociate into guanosine triphosphate (GTP)-bound α subunits and a complex of β and γ subunits after interaction with receptors. The GTP-α subunit complex activates appropriate effectors, such as adenylyl cyclase, retinal phosphodiesterase, phospholipase C, and ion channels. G protein βγ subunits have been found to have regulatory effects on certain types of adenylyl cyclase. In the presence of G, the at subunit of the G protein that activates adenylyl cyclase, one form of adenylyl cyclase was inhibited by βγ, some forms were activated by βγ, and some forms were not affected by βγ. These interactions suggest mechanisms for communication between distinct signal-transducing pathways.

Original languageEnglish (US)
Pages (from-to)1500-1503
Number of pages4
JournalScience
Volume254
Issue number5037
StatePublished - Dec 6 1991

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Protein Subunits
GTP-Binding Proteins
Adenylyl Cyclases
Carrier Proteins
Guanosine Triphosphate
Phosphoric Diester Hydrolases
Type C Phospholipases
Ion Channels
Signal Transduction

ASJC Scopus subject areas

  • General

Cite this

Tang, W. J., & Gilman, A. G. (1991). Type-specific regulation of adenylyl cyclase by G protein βγ subunits. Science, 254(5037), 1500-1503.

Type-specific regulation of adenylyl cyclase by G protein βγ subunits. / Tang, Wei Jen; Gilman, Alfred G.

In: Science, Vol. 254, No. 5037, 06.12.1991, p. 1500-1503.

Research output: Contribution to journalArticle

Tang, WJ & Gilman, AG 1991, 'Type-specific regulation of adenylyl cyclase by G protein βγ subunits', Science, vol. 254, no. 5037, pp. 1500-1503.
Tang WJ, Gilman AG. Type-specific regulation of adenylyl cyclase by G protein βγ subunits. Science. 1991 Dec 6;254(5037):1500-1503.
Tang, Wei Jen ; Gilman, Alfred G. / Type-specific regulation of adenylyl cyclase by G protein βγ subunits. In: Science. 1991 ; Vol. 254, No. 5037. pp. 1500-1503.
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