Uncertainty in the niches that maintain haematopoietic stem cells

Mark J. Kiel, Sean J. Morrison

Research output: Contribution to journalReview article

439 Scopus citations

Abstract

Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain stem cells and regulate their maintenance. Cells at the interface of bone and the bone marrow (the endosteum) contribute to the creation of HSC niches. It remains uncertain whether this interface itself is a niche, or whether endosteal cells secrete factors that diffuse to nearby niches. Vascular and/or perivascular cells may also create niches as many HSCs are observed around sinusoidal blood vessels, and perivascular cells secrete factors that regulate HSC maintenance. Do endosteal and perivascular cells create distinct niches, or do they contribute to a common niche? We discuss a range of niche models consistent with recent evidence.

Original languageEnglish (US)
Pages (from-to)290-301
Number of pages12
JournalNature Reviews Immunology
Volume8
Issue number4
DOIs
StatePublished - Apr 1 2008

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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