Uncertainty in the niches that maintain haematopoietic stem cells

Mark J. Kiel, Sean J. Morrison

Research output: Contribution to journalArticle

431 Citations (Scopus)

Abstract

Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain stem cells and regulate their maintenance. Cells at the interface of bone and the bone marrow (the endosteum) contribute to the creation of HSC niches. It remains uncertain whether this interface itself is a niche, or whether endosteal cells secrete factors that diffuse to nearby niches. Vascular and/or perivascular cells may also create niches as many HSCs are observed around sinusoidal blood vessels, and perivascular cells secrete factors that regulate HSC maintenance. Do endosteal and perivascular cells create distinct niches, or do they contribute to a common niche? We discuss a range of niche models consistent with recent evidence.

Original languageEnglish (US)
Pages (from-to)290-301
Number of pages12
JournalNature Reviews Immunology
Volume8
Issue number4
DOIs
StatePublished - Apr 2008

Fingerprint

Hematopoietic Stem Cells
Uncertainty
Stem Cell Niche
Blood Vessels
Maintenance
Bone Marrow
Bone and Bones

ASJC Scopus subject areas

  • Immunology

Cite this

Uncertainty in the niches that maintain haematopoietic stem cells. / Kiel, Mark J.; Morrison, Sean J.

In: Nature Reviews Immunology, Vol. 8, No. 4, 04.2008, p. 290-301.

Research output: Contribution to journalArticle

@article{169dbe1dc1c040cfac54e04986e6c900,
title = "Uncertainty in the niches that maintain haematopoietic stem cells",
abstract = "Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain stem cells and regulate their maintenance. Cells at the interface of bone and the bone marrow (the endosteum) contribute to the creation of HSC niches. It remains uncertain whether this interface itself is a niche, or whether endosteal cells secrete factors that diffuse to nearby niches. Vascular and/or perivascular cells may also create niches as many HSCs are observed around sinusoidal blood vessels, and perivascular cells secrete factors that regulate HSC maintenance. Do endosteal and perivascular cells create distinct niches, or do they contribute to a common niche? We discuss a range of niche models consistent with recent evidence.",
author = "Kiel, {Mark J.} and Morrison, {Sean J.}",
year = "2008",
month = "4",
doi = "10.1038/nri2279",
language = "English (US)",
volume = "8",
pages = "290--301",
journal = "Nature Reviews Immunology",
issn = "1474-1733",
publisher = "Nature Publishing Group",
number = "4",

}

TY - JOUR

T1 - Uncertainty in the niches that maintain haematopoietic stem cells

AU - Kiel, Mark J.

AU - Morrison, Sean J.

PY - 2008/4

Y1 - 2008/4

N2 - Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain stem cells and regulate their maintenance. Cells at the interface of bone and the bone marrow (the endosteum) contribute to the creation of HSC niches. It remains uncertain whether this interface itself is a niche, or whether endosteal cells secrete factors that diffuse to nearby niches. Vascular and/or perivascular cells may also create niches as many HSCs are observed around sinusoidal blood vessels, and perivascular cells secrete factors that regulate HSC maintenance. Do endosteal and perivascular cells create distinct niches, or do they contribute to a common niche? We discuss a range of niche models consistent with recent evidence.

AB - Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain stem cells and regulate their maintenance. Cells at the interface of bone and the bone marrow (the endosteum) contribute to the creation of HSC niches. It remains uncertain whether this interface itself is a niche, or whether endosteal cells secrete factors that diffuse to nearby niches. Vascular and/or perivascular cells may also create niches as many HSCs are observed around sinusoidal blood vessels, and perivascular cells secrete factors that regulate HSC maintenance. Do endosteal and perivascular cells create distinct niches, or do they contribute to a common niche? We discuss a range of niche models consistent with recent evidence.

UR - http://www.scopus.com/inward/record.url?scp=41149109622&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=41149109622&partnerID=8YFLogxK

U2 - 10.1038/nri2279

DO - 10.1038/nri2279

M3 - Article

C2 - 18323850

AN - SCOPUS:41149109622

VL - 8

SP - 290

EP - 301

JO - Nature Reviews Immunology

JF - Nature Reviews Immunology

SN - 1474-1733

IS - 4

ER -