Uncoupling nuclear receptor LXR and cholesterol metabolism in cancer

Fabiola Bovenga, Carlo Sabbà, Antonio Moschetta

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

Liver X receptors (LXRs) are members of the nuclear receptor superfamily of DNA-binding transcription factors and act as sensors of cholesterol homeostasis. Under normal conditions, when intracellular cholesterol concentration increases, cells synthesize oxysterols and activate the LXR transcriptional network to drive cholesterol efflux and reduce cholesterol influx and synthesis. During normal and cancer cell proliferation, there is a net uncoupling between intracellular cholesterol increase and LXR activation resulting from the reduced intracellular oxysterol concentration. This review dissects the novel mechanisms of a previously unrecognized metabolic uncoupling, supporting the activation of the LXR axis as a bona fide therapeutic approach in cancer.

Original languageEnglish (US)
Pages (from-to)517-526
Number of pages10
JournalCell Metabolism
Volume21
Issue number4
DOIs
StatePublished - Apr 7 2015

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Physiology

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