Undermining the endothelium by ablation of MAPK-MEF2 signaling

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Numerous stimuli activate Big MAPK-1 (BMK1), an MAPK that activates the myocyte enhancer factor-2 (MEF2) transcription factor. Conditional gene deletion showed BMK1 to be required for survival of endothelial cells (see the related article beginning on page 1138). An active form of MEF2C could partially bypass the requirement for BMK1 for endothelial cell survival in vitro. These findings reveal an essential role for BMK1-MEF2 signaling in an endothelial cell survival pathway and raise interesting questions about the molecular basis of this response.

Original languageEnglish (US)
Pages (from-to)1110-1112
Number of pages3
JournalJournal of Clinical Investigation
Volume113
Issue number8
DOIs
StatePublished - Apr 2004

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MEF2 Transcription Factors
Endothelium
Endothelial Cells
Cell Survival
Gene Deletion
Transcription Factors

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Undermining the endothelium by ablation of MAPK-MEF2 signaling. / Olson, Eric N.

In: Journal of Clinical Investigation, Vol. 113, No. 8, 04.2004, p. 1110-1112.

Research output: Contribution to journalArticle

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