Understanding clinical trial outcomes: Design, analysis, and interpretation

Heidi T. Jacobe, Justin J. Leitenberger, Paul R. Bergstresser

Research output: Contribution to journalReview article

6 Scopus citations

Abstract

Outcomes (a variable intended for comparison between groups) are integral to the design, conduct, and data analysis of a clinical trial. They are broadly divided into four categories: physician based, patient reported, economic based, and technology based. Each is used in dermatology to some degree, but no consensus exists as to what type of outcome or degree of validation should be employed. This is problematical because poor quality outcomes or their incorrect use may invalidate the results of a clinical trial. Despite their importance, outcome measures in dermatology receive little attention. The present authors aim to provide an overview of important considerations for outcome measures and a practical approach to their analysis.

Original languageEnglish (US)
Pages (from-to)77-85
Number of pages9
JournalDermatologic Therapy
Volume20
Issue number2
DOIs
StatePublished - Mar 1 2007

Keywords

  • Clinical trial design
  • Outcome measure
  • Statistical analysis

ASJC Scopus subject areas

  • Dermatology

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