Unique mutation patterns in anaplastic thyroid cancer identified by comprehensive genomic profiling

Saad A. Khan, Bo Ci, Yang Xie, David E. Gerber, Muhammad S. Beg, Steven I. Sherman, Maria E. Cabanillas, Naifa L. Busaidy, Barbara A. Burtness, Andreas M. Heilmann, Mark Bailey, Jeffrey S. Ross, David J. Sher, Siraj M. Ali

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Introduction: Anaplastic thyroid cancer (ATC) is a highly aggressive thyroid cancer. Those ATC with genomic alterations (GAs) in TSC2, ALK, and BRAF may respond to targeted therapies. Methods: Comprehensive genomic profiling on 90 ATC specimens identified base substitutions, short insertions and deletions, amplifications, copy number alterations, and genomic rearrangements in up to 315 cancer-related genes and 28 genes commonly rearranged in cancer. Results: Median patient age was 65 (range, 33-86) years, 50 patients were male. There was a mean of 4.2 GA per case, range 1-11. The most common GA were TP53 (66%), BRAF (34%), TERT (32%), CDKN2A (32%), and NRAS (26%). BRAF V600E and NRAS/HRAS/KRAS alteration were mutually exclusive. BRAF, CDKN2A, PIK3CA, and JAK2 were more frequent in patients >70 years of age; while myc, PTEN, and NRAS were more common in those ≤50 years. Conclusion: ATC shows many GA with potential therapeutic significance and suggesting different molecular pathways can lead to ATC.

Original languageEnglish (US)
Pages (from-to)1928-1934
Number of pages7
JournalHead and Neck
Volume41
Issue number6
DOIs
StatePublished - Jun 2019

Keywords

  • anaplastic
  • neoplasms
  • thyroid

ASJC Scopus subject areas

  • Otorhinolaryngology

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