Unique neuroradiological findings in propionic acidemia

Cory M. Pfeifer, Dane C. Van Tassel, Jeffrey H. Miller

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Propionic acidemia is a rare metabolic disorder that affects the catabolism of branched-chain amino acids and oddchain fatty acids. Propionic acidemia is one of the least common organic acidemias. Presented here are manifestations not previously characterized. The first case is an infant with diffuse subcortical diffusion restriction and vermian atrophy. The second case is an adolescent with asymmetric cortical volume loss and contralateral cortical diffusion restriction. These unique brain MRI findings of propionic acidemia may aid the neuroradiologist in guiding genetic testing for occult metabolic disease.

Original languageEnglish (US)
Pages (from-to)1207-1211
Number of pages5
JournalRadiology Case Reports
Volume13
Issue number6
DOIs
StatePublished - Dec 1 2018

Keywords

  • Metabolic crisis
  • Organic aciduria
  • Propionic acidemia

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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