University of California/Davis Interdepartmental Conference on gram-negative septicemia

L. S. Young, R. A. Proctor, B. Beutler, W. R. McCabe, J. N. Sheagren

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Gram-negative septicemia remains one of the most serious forms of hospital-acquired infection. The most consistently virulent component of the gram-negative lipopolysaccharide (endotoxin) appears to be lipid A. Elucidation of the structure-function relationships of lipid A and the biochemical configurations required for endotoxicity makes possible the design of lipopolysaccharide antagonists and/or the production of poly- or monoclonal antibodies that may abrogate the biologic effects of endotoxin. The mechanisms of activity of lipopolysaccharide and the pathophysiologic events it triggers are now better understood than in the recent past. Lipid A triggers the release of mediators such as cachectin (tumor necrosis factor), thereby initiating a cascade of potentially lethal events. Although recent studies indicate no routine role for corticosteroids in gram-negative septic shock or acute respiratory distress syndrome, considerable progress has been made in the development of effective antibiotics. Recent studies of septicemia in neutropenic patients show survival rates significantly higher than those reported more than two decades ago.

Original languageEnglish (US)
Pages (from-to)666-687
Number of pages22
JournalReviews of Infectious Diseases
Volume13
Issue number4
StatePublished - 1991

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Lipid A
Lipopolysaccharides
Sepsis
Endotoxins
Adult Respiratory Distress Syndrome
Septic Shock
Cross Infection
Adrenal Cortex Hormones
Survival Rate
Tumor Necrosis Factor-alpha
Monoclonal Antibodies
Anti-Bacterial Agents

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Young, L. S., Proctor, R. A., Beutler, B., McCabe, W. R., & Sheagren, J. N. (1991). University of California/Davis Interdepartmental Conference on gram-negative septicemia. Reviews of Infectious Diseases, 13(4), 666-687.

University of California/Davis Interdepartmental Conference on gram-negative septicemia. / Young, L. S.; Proctor, R. A.; Beutler, B.; McCabe, W. R.; Sheagren, J. N.

In: Reviews of Infectious Diseases, Vol. 13, No. 4, 1991, p. 666-687.

Research output: Contribution to journalArticle

Young, LS, Proctor, RA, Beutler, B, McCabe, WR & Sheagren, JN 1991, 'University of California/Davis Interdepartmental Conference on gram-negative septicemia', Reviews of Infectious Diseases, vol. 13, no. 4, pp. 666-687.
Young, L. S. ; Proctor, R. A. ; Beutler, B. ; McCabe, W. R. ; Sheagren, J. N. / University of California/Davis Interdepartmental Conference on gram-negative septicemia. In: Reviews of Infectious Diseases. 1991 ; Vol. 13, No. 4. pp. 666-687.
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