Unlocking the Non-invasive Assessment of Conduit and Reservoir Function in the Aorta

Adelaide de Vecchi, Alessandro Faraci, Joao Filipe Fernandes, David Marlevi, Hannah Bellsham-Revell, Tarique Hussain, Nidhin Laji, Bram Ruijsink, James Wong, Reza Razavi, David Anderson, Caner Salih, Kuberan Pushparajah, David Nordsletten, Pablo Lamata

Research output: Contribution to journalArticlepeer-review

Abstract

Aortic surgeries in congenital conditions, such as hypoplastic left heart syndrome (HLHS), aim to restore and maintain the conduit and reservoir functions of the aorta. We proposed a method to assess these two functions based on 4D flow MRI, and we applied it to study the aorta in pre-Fontan HLHS. Ten pre-Fontan HLHS patients and six age-matched controls were studied to derive the advective pressure difference and viscous dissipation for conduit function, and pulse wave velocity and elastic modulus for reservoir function. The reconstructed neo-aorta in HLHS subjects achieved a good conduit function at a cost of an impaired reservoir function (69.7% increase of elastic modulus). The native descending HLHS aorta displayed enhanced reservoir (elastic modulus being 18.4% smaller) but impaired conduit function (three-fold increase in peak advection). A non-invasive and comprehensive assessment of aortic conduit and reservoir functions is feasible and has potentially clinical relevance in congenital vascular conditions. Graphical abstract: [Figure not available: see fulltext.].

Original languageEnglish (US)
JournalJournal of cardiovascular translational research
DOIs
StateAccepted/In press - 2022

Keywords

  • 4D flow
  • Aorta
  • Conduit function
  • Hypoplastic left heart syndrome
  • Reservoir function

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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