Unusual case of metastatic neuroendocrine tumor

Michele A. Manahan, Alan P B Dackiw, Douglas W. Ball, Martha A. Zeiger

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Objective: To report a rare case of metastatic growth hormone (GH)-secreting pituitary carcinoma causing acromegaly. Methods: We present a case report and review the available literature on this topic. Results: A 68-year-old woman presented with persistent acromegaly after treatment for a GH-secreting pituitary adenoma. Evaluation of long-standing cervical adenopathy revealed findings consistent with a metastatic neuroendocrine tumor. Further work-up revealed additional thyroid, parathyroid, and cervical masses. After operative treatment including total thyroidectomy, subtotal parathyroidectomy, partial thymectomy, and right modified radical neck dissection, the patient's symptoms diminished, and her GH levels approached the normal range. Surgical pathology findings were consistent with a GH-secreting pituitary carcinoma metastatic to the cervical lymph nodes, multinodular thyroid hyperplasia with a focus of papillary microcarcinoma, and parathyroid hyperplasia. Conclusion: Overall, pituitary carcinomas are extremely rare. To date, about 100 cases have been reported in the world's literature, and of these, only 19 cases originated from GH-secreting cells. Our examination of the symptoms, signs, diagnosis, and treatment of our patient, in comparison with the previously reported cases, should enhance awareness of this unusual disease process.

Original languageEnglish (US)
Pages (from-to)72-76
Number of pages5
JournalEndocrine Practice
Volume13
Issue number1
StatePublished - Jan 2007

Fingerprint

Neuroendocrine Tumors
Growth Hormone
Pituitary Neoplasms
Acromegaly
Hyperplasia
Thyroid Gland
Growth Hormone-Secreting Pituitary Adenoma
Thymectomy
Surgical Pathology
Parathyroidectomy
Neck Dissection
Thyroidectomy
Signs and Symptoms
Reference Values
Therapeutics
Lymph Nodes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Manahan, M. A., Dackiw, A. P. B., Ball, D. W., & Zeiger, M. A. (2007). Unusual case of metastatic neuroendocrine tumor. Endocrine Practice, 13(1), 72-76.

Unusual case of metastatic neuroendocrine tumor. / Manahan, Michele A.; Dackiw, Alan P B; Ball, Douglas W.; Zeiger, Martha A.

In: Endocrine Practice, Vol. 13, No. 1, 01.2007, p. 72-76.

Research output: Contribution to journalArticle

Manahan, MA, Dackiw, APB, Ball, DW & Zeiger, MA 2007, 'Unusual case of metastatic neuroendocrine tumor', Endocrine Practice, vol. 13, no. 1, pp. 72-76.
Manahan MA, Dackiw APB, Ball DW, Zeiger MA. Unusual case of metastatic neuroendocrine tumor. Endocrine Practice. 2007 Jan;13(1):72-76.
Manahan, Michele A. ; Dackiw, Alan P B ; Ball, Douglas W. ; Zeiger, Martha A. / Unusual case of metastatic neuroendocrine tumor. In: Endocrine Practice. 2007 ; Vol. 13, No. 1. pp. 72-76.
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