Update on the treatment and prevention of ischaemic stroke

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Abstract

Stroke continues to have a devastating impact on public health. Recent epidemiological studies suggest that stroke is becoming more common, perhaps due to the ageing of the population and increased survival of patients with cardiac disease. There are specific and well-defined risk factors in patients with stroke, the most important being hypertension. Treatment options to reverse the effect of acute ischaemic stroke are limited. The only approved therapy is intravenous tissue plasminogen activator (tPA). The disadvantage of tPA treatment is a rate of symptomatic haemorrhage of about 6%. Newer stroke prevention options are currently being investigated including statins, oestrogen, angiotensin converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs). The challenge for physicians is to select the most effective intervention, and this depends on our knowledge of the underlying stroke mechanism and the patient's risk factors.

Original languageEnglish (US)
Pages (from-to)438-441
Number of pages4
JournalCurrent Medical Research and Opinion
Volume19
Issue number5
DOIs
StatePublished - Aug 26 2003

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Keywords

  • Angiotensin receptor blockers
  • Cerebrovascular disease
  • Hypertension
  • Ischaemic stroke
  • Tissue plasminogen activators

ASJC Scopus subject areas

  • Medicine(all)

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