Uric acid metabolism and uric acid stones

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Citations (Scopus)

Abstract

Uric acid nephrolithiasis comprises 8-10% of patients with kidney stone disease. However, this prevalence is higher in particular ethnic populations and in certain regions of the world. The major pathophysiologic mechanism for uric acid nephrolithiasis is unduly acidic urine. At a urinary pH below 5.5, the concentration of sparingly soluble uric acid increases and promotes the formation of uric acid stones. Unduly acidic urine is likely due to defective renal ammoniagenesis. Moreover, emerging studies suggest that increased endogenous acid production, in addition to defective urinary ammonium buffering, may also be responsible for the abnormally acidic urine in this population. The underlying mechanism of low urinary ammonium and increased endogenous acid production has been linked to the metabolic syndrome and may also be associated with renal fat accumulation in the kidney. Although low urinary pH is necessary, it alone is not sufficient for uric acid crystal precipitation. This implies the potential role of inhibitors and/or promoters of uric acid crystallization.

Original languageEnglish (US)
Title of host publicationUrinary Tract Stone Disease
PublisherSpringer London
Pages185-193
Number of pages9
ISBN (Print)9781848003613
DOIs
StatePublished - 2011

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Uric Acid
Nephrolithiasis
Urine
Kidney
Ammonium Compounds
Acids
Kidney Calculi
Kidney Diseases
Crystallization
Population
Fats

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sakhaee, K. (2011). Uric acid metabolism and uric acid stones. In Urinary Tract Stone Disease (pp. 185-193). Springer London. https://doi.org/10.1007/978-1-84800-362-0_15

Uric acid metabolism and uric acid stones. / Sakhaee, Khashayar.

Urinary Tract Stone Disease. Springer London, 2011. p. 185-193.

Research output: Chapter in Book/Report/Conference proceedingChapter

Sakhaee, K 2011, Uric acid metabolism and uric acid stones. in Urinary Tract Stone Disease. Springer London, pp. 185-193. https://doi.org/10.1007/978-1-84800-362-0_15
Sakhaee K. Uric acid metabolism and uric acid stones. In Urinary Tract Stone Disease. Springer London. 2011. p. 185-193 https://doi.org/10.1007/978-1-84800-362-0_15
Sakhaee, Khashayar. / Uric acid metabolism and uric acid stones. Urinary Tract Stone Disease. Springer London, 2011. pp. 185-193
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