Uric Acid Stones

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Uric acid stones constitute around 10-20% of kidney stones in the general stone-forming population, but are particularly more prevalent among obese and diabetic kidney stone formers and in patients with gout. The major risk factor predisposing to uric acid stone formation is an overly acidic urine (urinary pH <5.5), while hyperuricosuria and low urine volume are less commonly observed risk factors. Since urine pH is a key determinant of uric acid solubility in urine, uric acid stones can be dissolved with urinary alkalinization. Management of uric acid stones is primarily medical - urinary alkalinization through reduction in dietary acid ash intake and supplementation with potassium citrate or sodium bicarbonate. Urological intervention is generally reserved for cases of severe obstruction, progressive decline in renal function, infection or intractable pain.

Original languageEnglish (US)
Title of host publicationUrinary Stones
Subtitle of host publicationMedical and Surgical Management
PublisherWiley Blackwell
Pages26-35
Number of pages10
ISBN (Electronic)9781118405390
ISBN (Print)9781118405437
DOIs
Publication statusPublished - Feb 21 2014

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Keywords

  • Hyperuricosuria
  • Nephrolithiasis
  • Stones
  • Uric acid
  • Urine pH
  • Urolithiasis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Maalouf, N. M. (2014). Uric Acid Stones. In Urinary Stones: Medical and Surgical Management (pp. 26-35). Wiley Blackwell. https://doi.org/10.1002/9781118405390.ch3