Uromodulin in mineral metabolism

Matthias T.F. Wolf, Jing Zhang, Mingzhu Nie

Research output: Contribution to journalReview article

Abstract

Purpose of reviewUromodulin (UMOD), also known as Tamm-Horsfall protein, is the most abundant protein in human urine. UMOD has multiple functions such as protection against urinary tract infections and nephrolithiasis. This review outlines recent progress made in UMOD's role in renal physiology, tubular transport, and mineral metabolism.Recent findingsUMOD is mostly secreted in the thick ascending limb (TAL) and to a lesser degree in the distal convoluted tubule (DCT). UMOD secretion is regulated by the calcium-sensing receptor. UMOD upregulates ion channels [e.g., renal outer medullary potassium channel, transient receptor potential cation channel subfamily V member 5, and transient receptor potential melastatin 6 (TRPM6)] and cotransporters [e.g., Na+,K+,2Cl- cotransporter (NKCC2) and sodium-chloride cotransporter (NCC)] in the TAL and DCT. Higher serum UMOD concentrations have been associated with higher renal function and preserved renal reserve. Higher serum UMOD has also been linked to a lower risk of cardiovascular disease and diabetes mellitus.SummaryWith better serum UMOD detection assays the extent of different functions for UMOD is still expanding. Urinary UMOD regulates different tubular ion channels and cotransporters. Variations of urinary UMOD secretion can so contribute to common disorders such as hypertension or nephrolithiasis.

Original languageEnglish (US)
Pages (from-to)481-489
Number of pages9
JournalCurrent opinion in nephrology and hypertension
Volume28
Issue number5
DOIs
StatePublished - Sep 1 2019

Keywords

  • Na,K,2Cl cotransporter 2
  • Tamm-Horsfall protein
  • distal convoluted tubule
  • renal outer medullary potassium channel
  • sodium-chloride cotransporter
  • thick ascending limb
  • transient receptor potential cation channel subfamily V member 5
  • transient receptor potential melastatin 6
  • uromodulin

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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