US wingspan registry: 12-month follow-up results

David J. Fiorella, Aquilla S. Turk, Elad I. Levy, G. Lee Pride, Henry H. Woo, Felipe C. Albuquerque, Babu G. Welch, David B. Niemann, Beverly Aagaard-Kienitz, Peter A. Rasmussen, L. Nelson Hopkins, Thomas J. Masaryk, Cameron G. McDougall

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

Background and Purpose- The purpose of this study is to present 12-month follow-up results for a series of patients undergoing percutaneous transluminal angioplasty and stenting with the Gateway-Wingspan stenting system (Boston Scientific) for the treatment of symptomatic intracranial atherostenosis. Methods- Clinical and angiographic follow-up results were recorded for patients from 5 participating institutions. Primary end points were stroke or death within 30 days of the stenting procedure or ipsilateral stroke after 30 days. Results- During a 21-month study period, 158 patients with 168 intracranial atherostenotic lesions (50% to 99%) were treated with the Gateway-Wingspan system. The average follow-up duration was 14.2 months with 143 patients having at least 3 months of clinical follow-up and 110 having at least 12 months. The cumulative rate of the primary end point was 15.7% for all patients and 13.9% for patients with high-grade (70% to 99%) stenosis. Of 13 ipsilateral strokes occurring after 30 days, 3 resulted in death. Of these strokes, 76.9% (10 of 13) occurred within the first 6 months of the stenting procedure and no events were recorded after 12 months. An additional 9 patients experienced ipsilateral transient ischemic attack after 30 days. Most postprocedural events (86%) could be attributed to interruption of antiplatelet medications (n=6), in-stent restenosis (n=12), or both (n=1). In 3 patients, the events were of uncertain etiology. Conclusions- After successful Wingspan percutaneous transluminal angioplasty and stenting, some patients continued to experience ipsilateral ischemic events. Most of these ischemic events occurred within 6 months of the procedure and were associated with the interruption of antiplatelet therapy or in-stent restenosis.

Original languageEnglish (US)
Pages (from-to)1976-1981
Number of pages6
JournalStroke
Volume42
Issue number7
DOIs
StatePublished - Jul 1 2011

    Fingerprint

Keywords

  • Wingspan
  • angioplasty
  • intracranial atheromatous disease
  • stenting
  • symptomatic intracranial stenosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Fiorella, D. J., Turk, A. S., Levy, E. I., Pride, G. L., Woo, H. H., Albuquerque, F. C., Welch, B. G., Niemann, D. B., Aagaard-Kienitz, B., Rasmussen, P. A., Hopkins, L. N., Masaryk, T. J., & McDougall, C. G. (2011). US wingspan registry: 12-month follow-up results. Stroke, 42(7), 1976-1981. https://doi.org/10.1161/STROKEAHA.111.613877