Use of Polar Picolyl Protecting Groups in Peptide Synthesis

Jose Rizo-Rey, Fernando Albericio, Guillermo Romero, Carlos García-Echeverría, Josep Claret, Carlos Muller, Ernest Giralt, Enrique Pedroso

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Protection of serine and threonine side chains with the 4-picolyl group and aspartic and glutamic acids with the 3-picolyl group is described. Picolyl-protected peptide segments are markedly more polar than benzylprotected analogues, which can facilitate their purification.

Original languageEnglish (US)
Pages (from-to)5386-5389
Number of pages4
JournalJournal of Organic Chemistry
Volume53
Issue number22
DOIs
StatePublished - Oct 1 1988

ASJC Scopus subject areas

  • Organic Chemistry

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    Rizo-Rey, J., Albericio, F., Romero, G., García-Echeverría, C., Claret, J., Muller, C., Giralt, E., & Pedroso, E. (1988). Use of Polar Picolyl Protecting Groups in Peptide Synthesis. Journal of Organic Chemistry, 53(22), 5386-5389. https://doi.org/10.1021/jo00257a044