Use of polar picolyl protecting groups in peptide synthesis

Jose Rizo-Rey, Fernando Albericio, Guillermo Romero, Carlos García-Echeverría, Josep Claret, Carlos Muller, Ernest Giralt, Enrique Pedroso

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Protection of serine and threonine side chains with the 4-picolyl group and aspartic and glutamic acids with the 3-picolyl group is described. Picolyl-protected peptide segments are markedly more polar than benzyl-protected analogues, which can facilitate their purification.

Original languageEnglish (US)
Pages (from-to)5386-5389
Number of pages4
JournalJournal of Organic Chemistry
Volume53
Issue number22
StatePublished - 1988

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Glutamates
Threonine
Serine
Purification
Peptides

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Rizo-Rey, J., Albericio, F., Romero, G., García-Echeverría, C., Claret, J., Muller, C., ... Pedroso, E. (1988). Use of polar picolyl protecting groups in peptide synthesis. Journal of Organic Chemistry, 53(22), 5386-5389.

Use of polar picolyl protecting groups in peptide synthesis. / Rizo-Rey, Jose; Albericio, Fernando; Romero, Guillermo; García-Echeverría, Carlos; Claret, Josep; Muller, Carlos; Giralt, Ernest; Pedroso, Enrique.

In: Journal of Organic Chemistry, Vol. 53, No. 22, 1988, p. 5386-5389.

Research output: Contribution to journalArticle

Rizo-Rey, J, Albericio, F, Romero, G, García-Echeverría, C, Claret, J, Muller, C, Giralt, E & Pedroso, E 1988, 'Use of polar picolyl protecting groups in peptide synthesis', Journal of Organic Chemistry, vol. 53, no. 22, pp. 5386-5389.
Rizo-Rey J, Albericio F, Romero G, García-Echeverría C, Claret J, Muller C et al. Use of polar picolyl protecting groups in peptide synthesis. Journal of Organic Chemistry. 1988;53(22):5386-5389.
Rizo-Rey, Jose ; Albericio, Fernando ; Romero, Guillermo ; García-Echeverría, Carlos ; Claret, Josep ; Muller, Carlos ; Giralt, Ernest ; Pedroso, Enrique. / Use of polar picolyl protecting groups in peptide synthesis. In: Journal of Organic Chemistry. 1988 ; Vol. 53, No. 22. pp. 5386-5389.
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