Use of 31P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia

A. R. Laptook, R. J T Corbett, R. Uauy, C. Mize, D. Mendelsohn, R. L. Nunnally

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

We investigated postasphyxial brain damage with 31P magnetic resonance spectroscopy (MRS) and correlated it with neurologic assessment and standard laboratory evaluation during the first 10 months of life in 1 infant, baby G. We compared these observations to 31P MRS data from 7 healthy term newborns, 1 normal infant examined serially over the first 8.5 months of life, and 5 other term infanta following perinatal asphyxia. MRS noninvasively provides biochemical correlates of the evolution of brain damage following perinatal asphyxia and suggests that pH derived from the inorganic phosphate peak may serve as a marker for brain injury.

Original languageEnglish (US)
Pages (from-to)709-712
Number of pages4
JournalNeurology
Volume39
Issue number5
DOIs
StatePublished - May 1989

ASJC Scopus subject areas

  • Clinical Neurology

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