Use of 31P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia

A. R. Laptook, R. J T Corbett, R. Uauy, C. Mize, D. Mendelsohn, R. L. Nunnally

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We investigated postasphyxial brain damage with 31P magnetic resonance spectroscopy (MRS) and correlated it with neurologic assessment and standard laboratory evaluation during the first 10 months of life in 1 infant, baby G. We compared these observations to 31P MRS data from 7 healthy term newborns, 1 normal infant examined serially over the first 8.5 months of life, and 5 other term infants following perinatal asphyxia. MRS noninvasively provides biochemical correlates of the evolution of brain damage following perinatal asphyxia and suggests that pH derived from the inorganic phosphate peak may serve as a marker for brain injury.

Original languageEnglish (US)
Pages (from-to)709-712
Number of pages4
JournalNeurology
Volume39
Issue number5
StatePublished - 1989

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Asphyxia
Magnetic Resonance Spectroscopy
Brain
Brain Injuries
Nervous System
Phosphates
Newborn Infant

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Laptook, A. R., Corbett, R. J. T., Uauy, R., Mize, C., Mendelsohn, D., & Nunnally, R. L. (1989). Use of 31P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia. Neurology, 39(5), 709-712.

Use of 31P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia. / Laptook, A. R.; Corbett, R. J T; Uauy, R.; Mize, C.; Mendelsohn, D.; Nunnally, R. L.

In: Neurology, Vol. 39, No. 5, 1989, p. 709-712.

Research output: Contribution to journalArticle

Laptook, AR, Corbett, RJT, Uauy, R, Mize, C, Mendelsohn, D & Nunnally, RL 1989, 'Use of 31P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia', Neurology, vol. 39, no. 5, pp. 709-712.
Laptook, A. R. ; Corbett, R. J T ; Uauy, R. ; Mize, C. ; Mendelsohn, D. ; Nunnally, R. L. / Use of 31P magnetic resonance spectroscopy to characterize evolving brain damage after perinatal asphyxia. In: Neurology. 1989 ; Vol. 39, No. 5. pp. 709-712.
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