TY - JOUR
T1 - Usefulness of Non-Invasive Measurement of Cardiac Output During Sub-Maximal Exercise to Predict Outcome in Patients With Chronic Heart Failure
AU - Goda, Ayumi
AU - Lang, Chim C.
AU - Williams, Paula
AU - Jones, Margaret
AU - Farr, Mary Jane
AU - Mancini, Donna M.
PY - 2009/12/1
Y1 - 2009/12/1
N2 - Peak oxygen consumption (Vo2) is a powerful prognostic predictor of survival in patients with chronic heart failure (CHF) because it provides an indirect assessment of a patient's ability to increase cardiac output (CO). However, many patients with CHF who undergo cardiopulmonary exercise testing are unable to perform maximal exercise. New metabolic carts coupled with the inert gas rebreathing technique provide a noninvasive measurement of CO. Whether the noninvasive measurement of CO at a fixed submaximal workload can predict outcome is unknown. This study's population comprised 259 patients (mean age 54 ± 14 years, mean left ventricular ejection fraction 27 ± 14%) with CHF who underwent symptom-limited incremental cardiopulmonary exercise testing. Vo2 and CO were measured at rest, at 25 W, and at peak exercise. Submaximal exercise was defined as <80% peak Vo2. Among 259 patients, 145 had Vo2 at 25 W <80% of peak. Vo2 at 25 W averaged 9.3 ± 1.8 ml/kg/min. This Vo2 represented 62 ± 11% of peak Vo2, which averaged 15.4 ± 4.4 ml/kg/min. Prospective follow-up averaged 521 ± 337 days. In this cohort, there were 15 outcome events (death, urgent heart transplantation, or implantation of a left ventricular assist device as a bridge to transplantation). On univariate Cox hazard analysis, CO at 25 W (hazard ratio 0.64, 95% confidence interval 0.48 to 0.84, p = 0.002) was found to be significant predictor of events of outcome. In conclusion, CO at 25 W measured noninvasively during submaximal exercise may have potential value as a predictor of outcomes in patients with CHF.
AB - Peak oxygen consumption (Vo2) is a powerful prognostic predictor of survival in patients with chronic heart failure (CHF) because it provides an indirect assessment of a patient's ability to increase cardiac output (CO). However, many patients with CHF who undergo cardiopulmonary exercise testing are unable to perform maximal exercise. New metabolic carts coupled with the inert gas rebreathing technique provide a noninvasive measurement of CO. Whether the noninvasive measurement of CO at a fixed submaximal workload can predict outcome is unknown. This study's population comprised 259 patients (mean age 54 ± 14 years, mean left ventricular ejection fraction 27 ± 14%) with CHF who underwent symptom-limited incremental cardiopulmonary exercise testing. Vo2 and CO were measured at rest, at 25 W, and at peak exercise. Submaximal exercise was defined as <80% peak Vo2. Among 259 patients, 145 had Vo2 at 25 W <80% of peak. Vo2 at 25 W averaged 9.3 ± 1.8 ml/kg/min. This Vo2 represented 62 ± 11% of peak Vo2, which averaged 15.4 ± 4.4 ml/kg/min. Prospective follow-up averaged 521 ± 337 days. In this cohort, there were 15 outcome events (death, urgent heart transplantation, or implantation of a left ventricular assist device as a bridge to transplantation). On univariate Cox hazard analysis, CO at 25 W (hazard ratio 0.64, 95% confidence interval 0.48 to 0.84, p = 0.002) was found to be significant predictor of events of outcome. In conclusion, CO at 25 W measured noninvasively during submaximal exercise may have potential value as a predictor of outcomes in patients with CHF.
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U2 - 10.1016/j.amjcard.2009.07.025
DO - 10.1016/j.amjcard.2009.07.025
M3 - Article
C2 - 19932792
AN - SCOPUS:71649091934
SN - 0002-9149
VL - 104
SP - 1556
EP - 1560
JO - American Journal of Cardiology
JF - American Journal of Cardiology
IS - 11
ER -