Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia

on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group

Research output: Contribution to journalArticle

Abstract

Objective: To determine the relationship between interventricular septal position (SP) and right ventricular systolic pressure (RVSP) and mortality in infants with severe BPD (sBPD). Study design: Infants with sBPD in the Children’s Hospitals Neonatal Database who had echocardiograms 34–44 weeks’ postmenstrual age (PMA) were included. SP and RVSP were categorized normal, abnormal (flattened/bowed SP or RVSP > 40 mmHg) or missing. Results: Of 1157 infants, 115 infants (10%) died. Abnormal SP or RVSP increased mortality (SP 19% vs. 8% normal/missing, RVSP 20% vs. 9% normal/missing, both p < 0.01) in unadjusted and multivariable models, adjusted for significant covariates (SP OR 1.9, 95% CI 1.2–3.0; RVSP OR 2.2, 95% CI 1.1–4.7). Abnormal parameters had high specificity (SP 82%; RVSP 94%), and negative predictive value (SP 94%, NPV 91%) for mortality. Conclusions: Abnormal SP or RVSP is independently associated with mortality in sBPD infants. Negative predictive values distinguish infants most likely to survive.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalJournal of Perinatology
Volume40
Issue number1
DOIs
StatePublished - Jan 1 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

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    on behalf of the Children’s Hospitals Neonatal Consortium Severe BPD Focus Group (2020). Utility of echocardiography in predicting mortality in infants with severe bronchopulmonary dysplasia. Journal of Perinatology, 40(1), 149-156. https://doi.org/10.1038/s41372-019-0508-5