Utilization of omeprazole to augment subtherapeutic voriconazole concentrations for treatment of aspergillus infections

Natalie K. Boyd, Cindy L. Zoellner, Mark A. Swancutt, Kavita P. Bhavan

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Voriconazole is the preferred antifungal agent for Aspergillus infections. Therapeutic drug monitoring is recommended to achieve target concentrations and prevent toxicity. However, variable pharmacokinetics, cytochrome P450 polymorphisms, and extensive drug-drug interactions can contribute to subtherapeutic concentrations. We report a voriconazole "boosting" effect of omeprazole to achieve target concentrations for the treatment of Aspergillus in a patient who had persistently subtherapeutic trough concentrations.

Original languageEnglish (US)
Pages (from-to)6001-6002
Number of pages2
JournalAntimicrobial agents and chemotherapy
Volume56
Issue number11
DOIs
StatePublished - Nov 2012

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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