UTSW small animal positron emission imager

Edward N. Tsyganov, Jon Anderson, Gary Arbique, Anca Constantinescu, Marc Jennewein, Padmakar V. Kulkarni, Ralph P. Mason, Roderick W. McColl, Orhan K. Öz, Robert W. Parkey, Edmond Richer, Frank Rösch, Serguei Y. Seliounine, Nikolai V. Slavine, Suresh C. Srivastava, Philip E. Thorpe, Alexander I. Zinchenko, Peter P. Antich

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A Small Animal Imager (SAI) for PET has been designed, built, tested in phantoms, and applied to investigations in mice and rats. The device uses principles based on γ-ray induced scintillation in crossed fiber optic detectors connected to Position Sensitive Photomultiplier Tubes (PSPMT). Each detector consists of an epoxied stack of 28 layers of 135 round 1 mm BCF-10 scintillating plastic fibers. The overlap region forms a 13.5 × 13.5 × 2.8 cm 3 detector volume. Scintillating light from the fibers is detected by two (X and Y directions) Hamamatsu R-2486 PSPMTs with 16 anode wires in each of two orthogonal directions. A centroid-finding algorithm gives the position of a light cluster on the face (photocathode) of a PSPMT. The accuracy of the reconstruction of an interaction position is essentially independent of light cluster position. This translates to a nearly Isotropic photon response for the entire detector. The system has been used to test several 3D image reconstruction algorithms, software modifications, and improvements. The sensitivity (∼12.6 cps/kBq at 9 cm inner diameter) and sub-millimeter spatial resolution (better than 1 mm in phantoms) obtained with an iterative algorithm incorporating system modeling make the SAI a relatively inexpensive high performance animal imager. The SAI is currently being used for imaging experiments in mice and rats.

Original languageEnglish (US)
Article number1710243
Pages (from-to)2591-2599
Number of pages9
JournalIEEE Transactions on Nuclear Science
Volume53
Issue number5
DOIs
StatePublished - Oct 2006

Fingerprint

Positrons
Image sensors
animals
positrons
Animals
Detectors
Photomultipliers
detectors
Rats
photomultiplier tubes
rats
mice
Photocathodes
Fibers
Scintillation
scintillating fibers
Image reconstruction
plastic fibers
Fiber optics
photocathodes

Keywords

  • Antibodies
  • Arsenic
  • FDG
  • Image reconstruction
  • Positron emission tomography
  • Small animal imaging

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Nuclear Energy and Engineering

Cite this

Tsyganov, E. N., Anderson, J., Arbique, G., Constantinescu, A., Jennewein, M., Kulkarni, P. V., ... Antich, P. P. (2006). UTSW small animal positron emission imager. IEEE Transactions on Nuclear Science, 53(5), 2591-2599. [1710243]. https://doi.org/10.1109/TNS.2006.876000

UTSW small animal positron emission imager. / Tsyganov, Edward N.; Anderson, Jon; Arbique, Gary; Constantinescu, Anca; Jennewein, Marc; Kulkarni, Padmakar V.; Mason, Ralph P.; McColl, Roderick W.; Öz, Orhan K.; Parkey, Robert W.; Richer, Edmond; Rösch, Frank; Seliounine, Serguei Y.; Slavine, Nikolai V.; Srivastava, Suresh C.; Thorpe, Philip E.; Zinchenko, Alexander I.; Antich, Peter P.

In: IEEE Transactions on Nuclear Science, Vol. 53, No. 5, 1710243, 10.2006, p. 2591-2599.

Research output: Contribution to journalArticle

Tsyganov, EN, Anderson, J, Arbique, G, Constantinescu, A, Jennewein, M, Kulkarni, PV, Mason, RP, McColl, RW, Öz, OK, Parkey, RW, Richer, E, Rösch, F, Seliounine, SY, Slavine, NV, Srivastava, SC, Thorpe, PE, Zinchenko, AI & Antich, PP 2006, 'UTSW small animal positron emission imager', IEEE Transactions on Nuclear Science, vol. 53, no. 5, 1710243, pp. 2591-2599. https://doi.org/10.1109/TNS.2006.876000
Tsyganov EN, Anderson J, Arbique G, Constantinescu A, Jennewein M, Kulkarni PV et al. UTSW small animal positron emission imager. IEEE Transactions on Nuclear Science. 2006 Oct;53(5):2591-2599. 1710243. https://doi.org/10.1109/TNS.2006.876000
Tsyganov, Edward N. ; Anderson, Jon ; Arbique, Gary ; Constantinescu, Anca ; Jennewein, Marc ; Kulkarni, Padmakar V. ; Mason, Ralph P. ; McColl, Roderick W. ; Öz, Orhan K. ; Parkey, Robert W. ; Richer, Edmond ; Rösch, Frank ; Seliounine, Serguei Y. ; Slavine, Nikolai V. ; Srivastava, Suresh C. ; Thorpe, Philip E. ; Zinchenko, Alexander I. ; Antich, Peter P. / UTSW small animal positron emission imager. In: IEEE Transactions on Nuclear Science. 2006 ; Vol. 53, No. 5. pp. 2591-2599.
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