Vaccination of Lewis rats with temperature-sensitive mutants of Mycoplasma pulmonis

Adoptive transfer of immunity by spleen cells but not by sera

W. C. Lai, M. Bennett, Y. S. Lu, S. P. Pakes

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Temperature-sensitive mutant vaccines protect rats against Mycoplasma pulmonis infection. The role of the humoral or cellular immune response in resistance to mycoplasma infection was investigated by adoptivetransfer experiments. Spleen cells from Lewis rats vaccinated but not challenged with wild-type organisms (vaccinated) and spleen cells from rats vaccinated (or not) and challenged were effective in preventing syngeneic recipients from developing respiratory disease. There was also a significant reduction in the incidence and number of challenging organisms in the respiratorysystem. In contrast, sera from the same donors had no detectable effect on the number of mycoplasmas recovered or on lesion development in the respiratory tract. We conclude that cellular immunity rather than humoral immunity generated in vaccinated rats confers protection against subsequent infection.

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalInfection and Immunity
Volume59
Issue number1
StatePublished - 1991

Fingerprint

Mycoplasma pulmonis
Adoptive Transfer
Adaptive Immunity
Vaccination
Spleen
Mycoplasma Infections
Temperature
Humoral Immunity
Serum
Cellular Immunity
Mycoplasma
Respiratory System
Vaccines
Incidence
Infection

ASJC Scopus subject areas

  • Immunology

Cite this

Vaccination of Lewis rats with temperature-sensitive mutants of Mycoplasma pulmonis : Adoptive transfer of immunity by spleen cells but not by sera. / Lai, W. C.; Bennett, M.; Lu, Y. S.; Pakes, S. P.

In: Infection and Immunity, Vol. 59, No. 1, 1991, p. 346-350.

Research output: Contribution to journalArticle

@article{f1d325b2fe764e20b87e6e64d152bcad,
title = "Vaccination of Lewis rats with temperature-sensitive mutants of Mycoplasma pulmonis: Adoptive transfer of immunity by spleen cells but not by sera",
abstract = "Temperature-sensitive mutant vaccines protect rats against Mycoplasma pulmonis infection. The role of the humoral or cellular immune response in resistance to mycoplasma infection was investigated by adoptivetransfer experiments. Spleen cells from Lewis rats vaccinated but not challenged with wild-type organisms (vaccinated) and spleen cells from rats vaccinated (or not) and challenged were effective in preventing syngeneic recipients from developing respiratory disease. There was also a significant reduction in the incidence and number of challenging organisms in the respiratorysystem. In contrast, sera from the same donors had no detectable effect on the number of mycoplasmas recovered or on lesion development in the respiratory tract. We conclude that cellular immunity rather than humoral immunity generated in vaccinated rats confers protection against subsequent infection.",
author = "Lai, {W. C.} and M. Bennett and Lu, {Y. S.} and Pakes, {S. P.}",
year = "1991",
language = "English (US)",
volume = "59",
pages = "346--350",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "1",

}

TY - JOUR

T1 - Vaccination of Lewis rats with temperature-sensitive mutants of Mycoplasma pulmonis

T2 - Adoptive transfer of immunity by spleen cells but not by sera

AU - Lai, W. C.

AU - Bennett, M.

AU - Lu, Y. S.

AU - Pakes, S. P.

PY - 1991

Y1 - 1991

N2 - Temperature-sensitive mutant vaccines protect rats against Mycoplasma pulmonis infection. The role of the humoral or cellular immune response in resistance to mycoplasma infection was investigated by adoptivetransfer experiments. Spleen cells from Lewis rats vaccinated but not challenged with wild-type organisms (vaccinated) and spleen cells from rats vaccinated (or not) and challenged were effective in preventing syngeneic recipients from developing respiratory disease. There was also a significant reduction in the incidence and number of challenging organisms in the respiratorysystem. In contrast, sera from the same donors had no detectable effect on the number of mycoplasmas recovered or on lesion development in the respiratory tract. We conclude that cellular immunity rather than humoral immunity generated in vaccinated rats confers protection against subsequent infection.

AB - Temperature-sensitive mutant vaccines protect rats against Mycoplasma pulmonis infection. The role of the humoral or cellular immune response in resistance to mycoplasma infection was investigated by adoptivetransfer experiments. Spleen cells from Lewis rats vaccinated but not challenged with wild-type organisms (vaccinated) and spleen cells from rats vaccinated (or not) and challenged were effective in preventing syngeneic recipients from developing respiratory disease. There was also a significant reduction in the incidence and number of challenging organisms in the respiratorysystem. In contrast, sera from the same donors had no detectable effect on the number of mycoplasmas recovered or on lesion development in the respiratory tract. We conclude that cellular immunity rather than humoral immunity generated in vaccinated rats confers protection against subsequent infection.

UR - http://www.scopus.com/inward/record.url?scp=0026071017&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026071017&partnerID=8YFLogxK

M3 - Article

VL - 59

SP - 346

EP - 350

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 1

ER -