Vacuoles

C. J. Stefan, W. M. Henne, S. D. Emr

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Vacuoles and their mammalian counterparts, lysosomes, are membrane-bound cytoplasmic organelles that contain an assortment of soluble acid-dependent hydrolases and a set of highly glycosylated integral membrane proteins. Most notably, this organelle is an important site for the degradation of cellular lipids, membrane-associated proteins, and cytoplasmic proteins. In addition to its degradative functions, the vacuole/lysosome plays important roles in pH and ion homeostasis, nutrient storage, protein quality control, the innate immune pathway, and stress signaling responses. Accordingly, mis-regulation of lysosomal function has been implicated in several aspects of human disease, including neurodegenerative diseases.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Biological Chemistry
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Pages331-336
Number of pages6
ISBN (Electronic)9780123786319
ISBN (Print)9780123786302
DOIs
StatePublished - Feb 15 2013

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Vacuoles
Lysosomes
Organelles
Membrane Proteins
Neurodegenerative diseases
Hydrolases
Neurodegenerative Diseases
Quality Control
Lipids
Nutrients
Quality control
Proteins
Homeostasis
Cell Membrane
Ions
Membranes
Food
Degradation
Acids

Keywords

  • Autophagy
  • Contractile vacuole
  • Endocytosis
  • Endosomal sorting complexes required for transport (ESCRT) pathway
  • Endosome
  • Hydrolase
  • Lysosomal storage disease
  • Lysosome
  • Lysosome-related organelle
  • Multivesicular body
  • Pathogen-containing vacuole
  • V-ATPase

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Stefan, C. J., Henne, W. M., & Emr, S. D. (2013). Vacuoles. In Encyclopedia of Biological Chemistry: Second Edition (pp. 331-336). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-378630-2.00441-2

Vacuoles. / Stefan, C. J.; Henne, W. M.; Emr, S. D.

Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. p. 331-336.

Research output: Chapter in Book/Report/Conference proceedingChapter

Stefan, CJ, Henne, WM & Emr, SD 2013, Vacuoles. in Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., pp. 331-336. https://doi.org/10.1016/B978-0-12-378630-2.00441-2
Stefan CJ, Henne WM, Emr SD. Vacuoles. In Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc. 2013. p. 331-336 https://doi.org/10.1016/B978-0-12-378630-2.00441-2
Stefan, C. J. ; Henne, W. M. ; Emr, S. D. / Vacuoles. Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., 2013. pp. 331-336
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