Validated, electronic health record deployable prediction models for assessing patient risk of 30-day rehospitalization and mortality in older heart failure patients

Zubin J. Eapen, Li Liang, Gregg C. Fonarow, Paul A. Heidenreich, Lesley H. Curtis, Eric D. Peterson, Adrian F. Hernandez

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The study sought to derive and validate risk-prediction tools from a large nationwide registry linked with Medicare claims data. Background: Few clinical models have been developed utilizing data elements readily available in electronic health records (EHRs) to facilitate " real-time" risk estimation. Methods: Heart failure (HF) patients ≥65 years of age hospitalized in the GWTG-HF (Get With The Guidelines-Heart Failure) program were linked with Medicare claims from January 2005 to December 2009. Multivariable models were developed for 30-day mortality after admission, 30-day rehospitalization after discharge, and 30-day mortality/rehospitalization after discharge. Candidate variables were selected based on availability in EHRs and prognostic value. The models were validated in a 30% random sample and separately in patients with reduced and preserved ejection fraction (EF). Results: Among 33,349 patients at 160 hospitals, 3,002 (9.1%) died within 30 days of admission, 7,020 (22.8%) were rehospitalized within 30 days of discharge, and 8,374 (27.2%) died or were rehospitalized within 30 days of discharge. Compared with patients classified as low risk, high-risk patients had significantly higher odds of death (odds ratio [OR]: 8.82, 95% confidence interval [CI]: 7.58 to 10.26), rehospitalization (OR: 1.99, 95% CI: 1.86 to 2.13), and death/rehospitalization (OR: 2.65, 95% CI: 2.44 to 2.89). The 30-day mortality model demonstrated good discrimination (c-index 0.75) while the rehospitalization and death/rehospitalization models demonstrated more modest discrimination (c-indices of 0.59 and 0.62), with similar performance in the validation cohort and for patients with preserved and reduced EF. Conclusions: These predictive models allow for risk stratification of 30-day outcomes for patients hospitalized with HF and may provide a validated, point-of-care tool for clinical decision making.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalJACC: Heart Failure
Volume1
Issue number3
DOIs
StatePublished - Jun 2013
Externally publishedYes

Keywords

  • Electronic health records
  • Heart failure
  • Predictive models
  • Risk stratification

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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