Vascular targeting-a new approach to the therapy of solid tumors

Francis J. Burrows, Philip E. Thorpe

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

An attractive approach to the therapy of solid tumors is to attack the endothelial cells of the tumor vascular bed rather than the tumor cells themselves, which circumvents the problem of poor penetration of tumor masses by monoclonal antibodies and other macromolecules. In this review, we will discuss the drawbacks of targeting solid tumors and the advantages of the 'vascular targeting' approach, describe the validation of the concept in a mouse model and summarize the properties of tumor endothelial cell markers, which are candidates for vascular targeting in humans.

Original languageEnglish (US)
Pages (from-to)155-174
Number of pages20
JournalPharmacology and Therapeutics
Volume64
Issue number1
DOIs
StatePublished - 1994

Keywords

  • Therapy
  • endothelial cells
  • monoclonal antibodies
  • solid tumors
  • vascular targeting

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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