Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase

B. Escalante, W. C. Sessa, J R Falck, P. Yadagiri, M. L. Schwartzman

Research output: Contribution to journalArticle

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Abstract

We recently demonstrated that cortical microsomes from spontaneously hypertensive rats metabolize arachidonic acid via cytochrome P450 to ω- and ω-1 hydroxylated compounds, 19- and 20-hydroxyeicosatetraenoic acids (HETE). The vascular activities of 20-HETE and the two isomers of 19-HETE were examined in rat aortic rings. The HETEs produced concentration-dependent contractions of the aortic rings. The contraction elicited by 20-HETE was abolished partially by removal of endothelium and was inhibited completely by treatment with indomethacin and reversed to a relaxation response by treatment with the endoperoxide and thromboxane receptor antagonist SQ 29548. These data suggest that the vascular effects of 20-HETE depend on subsequent metabolism by cyclooxygenase.

Original languageEnglish (US)
Pages (from-to)229-232
Number of pages4
JournalJournal of Pharmacology and Experimental Therapeutics
Volume248
Issue number1
StatePublished - 1989

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Prostaglandin-Endoperoxide Synthases
Blood Vessels
Thromboxane Receptors
Hydroxyeicosatetraenoic Acids
Inbred SHR Rats
Microsomes
Arachidonic Acid
Indomethacin
Cytochrome P-450 Enzyme System
Endothelium
20-hydroxy-5,8,11,14-eicosatetraenoic acid

ASJC Scopus subject areas

  • Pharmacology

Cite this

Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase. / Escalante, B.; Sessa, W. C.; Falck, J R; Yadagiri, P.; Schwartzman, M. L.

In: Journal of Pharmacology and Experimental Therapeutics, Vol. 248, No. 1, 1989, p. 229-232.

Research output: Contribution to journalArticle

Escalante, B. ; Sessa, W. C. ; Falck, J R ; Yadagiri, P. ; Schwartzman, M. L. / Vasoactivity of 20-hydroxyeicosatetraenoic acid is dependent on metabolism by cyclooxygenase. In: Journal of Pharmacology and Experimental Therapeutics. 1989 ; Vol. 248, No. 1. pp. 229-232.
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AU - Schwartzman, M. L.

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