Vasoconstriction with norepinephrine causes less forearm % resistance than a reflex sympathetic vasoconstriction

Kenneth A. Jamerson, Shawna D. Smith, John V. Amerena, Eric Grant, Stevo Julius

Research output: Contribution to journalArticle

43 Citations (Scopus)

Abstract

We used the %-perfused human forearm model to assess the effects of vasoconstriction induced with norepinephrine on the extraction of glucose in the forearm in two groups of healthy young volunteers. The norepinephrine findings were compared with a previously studied group in which vasoconstriction had been caused by reflex activation of the sympathetic nervous system. The aim of the study was to determine the relative importance of hemodynamic and receptor- mediated mechanisms of % resistance. Plasma %, arterial and venous glucose samples, and forearm blood flow were measured at 10-minute intervals during a 30-minute baseline, a 60-minute intra-arterial % infusion, and during 30 minutes of % infusion plus vasoconstriction. Group 1 (n=14) had physiological vasoconstriction induced by inflation of bilateral thigh cuffs to 40 mm Hg to cause pooling of blood in the lower extremities and reflex vasoconstriction in the forearm; group 2 (n=8) had intra-arterial infusion of norepinephrine to achieve the same degree of vasoconstriction as seen with inflation of thigh cuffs in group 1. Subjects in group 3 (n=7) had infusion of intra-arterial norepinephrine to achieve a twofold increase in physiological vasoconstriction. With a physiological decrease in forearm blood flow (group 1), there was a 19% decrease in forearm blood flow resulting in a 23% reduction in glucose uptake in the forearm (P<.03). The same degree of reduction in forearm blood flow with a predominantly α-adrenergic agonist, norepinephrine (group 2), causes much less % resistance (a decrease in utilization of 13%) (P<.04). When forearm blood flow is decreased twofold over the physiological vasoconstriction (group 3), there is a 42% reduction in glucose uptake (P<.005). The larger degree of % resistance with mild (25%) reflex vasoconstriction when compared with an equal degree of vasoconstriction induced by norepinephrine may be due to activation of β-receptors during the reflex or to differences in the microcirculatory patterns with different modalities of vasoconstriction.

Original languageEnglish (US)
Pages (from-to)1006-1016
Number of pages11
JournalHypertension
Volume23
Issue number6
StatePublished - 1994

Fingerprint

Vasoconstriction
Forearm
Reflex
Norepinephrine
Intra Arterial Infusions
Glucose
Economic Inflation
Thigh
Adrenergic Agonists
Sympathetic Nervous System
Blood Group Antigens
Lower Extremity
Healthy Volunteers
Hemodynamics

Keywords

  • Forearm
  • Insulin resistance
  • Norepinephrine
  • Sympathetic nervous
  • System

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Vasoconstriction with norepinephrine causes less forearm % resistance than a reflex sympathetic vasoconstriction. / Jamerson, Kenneth A.; Smith, Shawna D.; Amerena, John V.; Grant, Eric; Julius, Stevo.

In: Hypertension, Vol. 23, No. 6, 1994, p. 1006-1016.

Research output: Contribution to journalArticle

Jamerson, KA, Smith, SD, Amerena, JV, Grant, E & Julius, S 1994, 'Vasoconstriction with norepinephrine causes less forearm % resistance than a reflex sympathetic vasoconstriction', Hypertension, vol. 23, no. 6, pp. 1006-1016.
Jamerson, Kenneth A. ; Smith, Shawna D. ; Amerena, John V. ; Grant, Eric ; Julius, Stevo. / Vasoconstriction with norepinephrine causes less forearm % resistance than a reflex sympathetic vasoconstriction. In: Hypertension. 1994 ; Vol. 23, No. 6. pp. 1006-1016.
@article{92b9bc399bf642b7ae3358fc1df21fed,
title = "Vasoconstriction with norepinephrine causes less forearm {\%} resistance than a reflex sympathetic vasoconstriction",
abstract = "We used the {\%}-perfused human forearm model to assess the effects of vasoconstriction induced with norepinephrine on the extraction of glucose in the forearm in two groups of healthy young volunteers. The norepinephrine findings were compared with a previously studied group in which vasoconstriction had been caused by reflex activation of the sympathetic nervous system. The aim of the study was to determine the relative importance of hemodynamic and receptor- mediated mechanisms of {\%} resistance. Plasma {\%}, arterial and venous glucose samples, and forearm blood flow were measured at 10-minute intervals during a 30-minute baseline, a 60-minute intra-arterial {\%} infusion, and during 30 minutes of {\%} infusion plus vasoconstriction. Group 1 (n=14) had physiological vasoconstriction induced by inflation of bilateral thigh cuffs to 40 mm Hg to cause pooling of blood in the lower extremities and reflex vasoconstriction in the forearm; group 2 (n=8) had intra-arterial infusion of norepinephrine to achieve the same degree of vasoconstriction as seen with inflation of thigh cuffs in group 1. Subjects in group 3 (n=7) had infusion of intra-arterial norepinephrine to achieve a twofold increase in physiological vasoconstriction. With a physiological decrease in forearm blood flow (group 1), there was a 19{\%} decrease in forearm blood flow resulting in a 23{\%} reduction in glucose uptake in the forearm (P<.03). The same degree of reduction in forearm blood flow with a predominantly α-adrenergic agonist, norepinephrine (group 2), causes much less {\%} resistance (a decrease in utilization of 13{\%}) (P<.04). When forearm blood flow is decreased twofold over the physiological vasoconstriction (group 3), there is a 42{\%} reduction in glucose uptake (P<.005). The larger degree of {\%} resistance with mild (25{\%}) reflex vasoconstriction when compared with an equal degree of vasoconstriction induced by norepinephrine may be due to activation of β-receptors during the reflex or to differences in the microcirculatory patterns with different modalities of vasoconstriction.",
keywords = "Forearm, Insulin resistance, Norepinephrine, Sympathetic nervous, System",
author = "Jamerson, {Kenneth A.} and Smith, {Shawna D.} and Amerena, {John V.} and Eric Grant and Stevo Julius",
year = "1994",
language = "English (US)",
volume = "23",
pages = "1006--1016",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Vasoconstriction with norepinephrine causes less forearm % resistance than a reflex sympathetic vasoconstriction

AU - Jamerson, Kenneth A.

AU - Smith, Shawna D.

AU - Amerena, John V.

AU - Grant, Eric

AU - Julius, Stevo

PY - 1994

Y1 - 1994

N2 - We used the %-perfused human forearm model to assess the effects of vasoconstriction induced with norepinephrine on the extraction of glucose in the forearm in two groups of healthy young volunteers. The norepinephrine findings were compared with a previously studied group in which vasoconstriction had been caused by reflex activation of the sympathetic nervous system. The aim of the study was to determine the relative importance of hemodynamic and receptor- mediated mechanisms of % resistance. Plasma %, arterial and venous glucose samples, and forearm blood flow were measured at 10-minute intervals during a 30-minute baseline, a 60-minute intra-arterial % infusion, and during 30 minutes of % infusion plus vasoconstriction. Group 1 (n=14) had physiological vasoconstriction induced by inflation of bilateral thigh cuffs to 40 mm Hg to cause pooling of blood in the lower extremities and reflex vasoconstriction in the forearm; group 2 (n=8) had intra-arterial infusion of norepinephrine to achieve the same degree of vasoconstriction as seen with inflation of thigh cuffs in group 1. Subjects in group 3 (n=7) had infusion of intra-arterial norepinephrine to achieve a twofold increase in physiological vasoconstriction. With a physiological decrease in forearm blood flow (group 1), there was a 19% decrease in forearm blood flow resulting in a 23% reduction in glucose uptake in the forearm (P<.03). The same degree of reduction in forearm blood flow with a predominantly α-adrenergic agonist, norepinephrine (group 2), causes much less % resistance (a decrease in utilization of 13%) (P<.04). When forearm blood flow is decreased twofold over the physiological vasoconstriction (group 3), there is a 42% reduction in glucose uptake (P<.005). The larger degree of % resistance with mild (25%) reflex vasoconstriction when compared with an equal degree of vasoconstriction induced by norepinephrine may be due to activation of β-receptors during the reflex or to differences in the microcirculatory patterns with different modalities of vasoconstriction.

AB - We used the %-perfused human forearm model to assess the effects of vasoconstriction induced with norepinephrine on the extraction of glucose in the forearm in two groups of healthy young volunteers. The norepinephrine findings were compared with a previously studied group in which vasoconstriction had been caused by reflex activation of the sympathetic nervous system. The aim of the study was to determine the relative importance of hemodynamic and receptor- mediated mechanisms of % resistance. Plasma %, arterial and venous glucose samples, and forearm blood flow were measured at 10-minute intervals during a 30-minute baseline, a 60-minute intra-arterial % infusion, and during 30 minutes of % infusion plus vasoconstriction. Group 1 (n=14) had physiological vasoconstriction induced by inflation of bilateral thigh cuffs to 40 mm Hg to cause pooling of blood in the lower extremities and reflex vasoconstriction in the forearm; group 2 (n=8) had intra-arterial infusion of norepinephrine to achieve the same degree of vasoconstriction as seen with inflation of thigh cuffs in group 1. Subjects in group 3 (n=7) had infusion of intra-arterial norepinephrine to achieve a twofold increase in physiological vasoconstriction. With a physiological decrease in forearm blood flow (group 1), there was a 19% decrease in forearm blood flow resulting in a 23% reduction in glucose uptake in the forearm (P<.03). The same degree of reduction in forearm blood flow with a predominantly α-adrenergic agonist, norepinephrine (group 2), causes much less % resistance (a decrease in utilization of 13%) (P<.04). When forearm blood flow is decreased twofold over the physiological vasoconstriction (group 3), there is a 42% reduction in glucose uptake (P<.005). The larger degree of % resistance with mild (25%) reflex vasoconstriction when compared with an equal degree of vasoconstriction induced by norepinephrine may be due to activation of β-receptors during the reflex or to differences in the microcirculatory patterns with different modalities of vasoconstriction.

KW - Forearm

KW - Insulin resistance

KW - Norepinephrine

KW - Sympathetic nervous

KW - System

UR - http://www.scopus.com/inward/record.url?scp=0028221181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028221181&partnerID=8YFLogxK

M3 - Article

VL - 23

SP - 1006

EP - 1016

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 6

ER -