Ventilatory acclimatization in awake guinea pigs raised at high altitude

Cuneyt Yilmaz, Deborah C. Hogg, Priya Ravikumar, Connie C W Hsia

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To determine if laboratory strains of guinea pigs bred at sea level (SL) are "pre-adapted" to high altitude (HA), we raised litter-matched weanling Hartley guinea pigs for 4 months at SL, intermediate altitude (IA, 1250 m) or HA (3800 m) and exposed them acutely to 100, 21 and 12% inspired O 2 at their respective altitude of residence. Control animals raised at SL were also exposed acutely to 10 and 8% inspired O2. In awake spontaneously breathing guinea pigs raised at SL, resting minute ventilation and tidal volume increased significantly when inspired O2 tension fell below about 60 mmHg. In guinea pigs raised at IA or HA, ventilation was higher at any given inspired O2 tension in direct relationship to the altitude of residence. Resting hematocrit was also higher in animals raised at HA than at SL. We conclude that the pattern of ventilatory acclimatization to HA exposure in Hartley guinea pigs is similar to that in laboratory rats and human lowlanders; therefore laboratory guinea pigs are not pre-adapted and are suitable animals for the study of adaptation to high altitude.

Original languageEnglish (US)
Pages (from-to)235-242
Number of pages8
JournalRespiratory Physiology and Neurobiology
Volume145
Issue number2-3
DOIs
StatePublished - Feb 2005

Fingerprint

Acclimatization
Guinea Pigs
Oceans and Seas
Ventilation
Tidal Volume
Hematocrit
Respiration

Keywords

  • Acclimatization of high altitude
  • Development
  • Guinea pig
  • High altitude
  • Hypoxia
  • Mammals
  • Ventilation
  • Ventilatory acclimatization
  • Ventilatory response

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Neuroscience(all)

Cite this

Ventilatory acclimatization in awake guinea pigs raised at high altitude. / Yilmaz, Cuneyt; Hogg, Deborah C.; Ravikumar, Priya; Hsia, Connie C W.

In: Respiratory Physiology and Neurobiology, Vol. 145, No. 2-3, 02.2005, p. 235-242.

Research output: Contribution to journalArticle

Yilmaz, Cuneyt ; Hogg, Deborah C. ; Ravikumar, Priya ; Hsia, Connie C W. / Ventilatory acclimatization in awake guinea pigs raised at high altitude. In: Respiratory Physiology and Neurobiology. 2005 ; Vol. 145, No. 2-3. pp. 235-242.
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