@article{977c28ddd4754adf875450fd6f15b83a,
title = "Ventral CA1 neurons store social memory",
abstract = "The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient role in social memory. Both the proportion of activated vCA1 cells and the strength and stability of the responding cells are greater in response to a familiar mouse than to a previously unencountered mouse. Optogenetic reactivation of vCA1 neurons that respond to the familiar mouse enabled memory retrieval and the association of these neurons with unconditioned stimuli. Thus, vCA1 neurons and their NAc shell projections are a component of the storage site of social memory.",
author = "Teruhiro Okuyama and Takashi Kitamura and Roy, {Dheeraj S.} and Shigeyoshi Itohara and Susumu Tonegawa",
note = "Funding Information: We thank C. Sun, X. Liu, S. LeBlanc, J. Derwin, W. Yu, F. Bushard, S. Huang, G. Das, T. O'Connor, J. Young, and L. Brenner for their help. Supported by the RIKEN Brain Science Institute, Howard Hughes Medical Institute, the JPB Foundation (to S.T.), and Japan Society for the Promotion of Science Grant-in-Aid (to T.O.). All data and computer codes necessary to understand and assess the conclusions of this research are available in the supplementary materials. AAV9-hSyn:DIO-eArchT3.0-EYFP, AAV9-TRE:FT-Slow, AAV9-TRE:ChR2-EYFP, and AAV9-TRE:EYFP were developed at MIT by the group of S.T.; virus plasmids are available through a material transfer agreement. The Trpc4-Cre transgenic mouse line was developed at RIKEN BSI by the group of S.I. and is available through a material transfer agreement. Publisher Copyright: {\textcopyright} 2016, American Association for the Advancement of Science. All rights reserved.",
year = "2016",
month = sep,
day = "30",
doi = "10.1126/science.aaf7003",
language = "English (US)",
volume = "353",
pages = "1536--1541",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6307",
}