Ventral CA1 neurons store social memory

Teruhiro Okuyama, Takashi Kitamura, Dheeraj S. Roy, Shigeyoshi Itohara, Susumu Tonegawa

Research output: Contribution to journalArticle

108 Citations (Scopus)

Abstract

The medial temporal lobe, including the hippocampus, has been implicated in social memory. However, it remains unknown which parts of these brain regions and their circuits hold social memory. Here, we show that ventral hippocampal CA1 (vCA1) neurons of a mouse and their projections to nucleus accumbens (NAc) shell play a necessary and sufficient role in social memory. Both the proportion of activated vCA1 cells and the strength and stability of the responding cells are greater in response to a familiar mouse than to a previously unencountered mouse. Optogenetic reactivation of vCA1 neurons that respond to the familiar mouse enabled memory retrieval and the association of these neurons with unconditioned stimuli. Thus, vCA1 neurons and their NAc shell projections are a component of the storage site of social memory.

Original languageEnglish (US)
Pages (from-to)1536-1541
Number of pages6
JournalScience
Volume353
Issue number6307
DOIs
StatePublished - Sep 30 2016

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Neurons
Nucleus Accumbens
Optogenetics
Temporal Lobe
Hippocampus
Brain

ASJC Scopus subject areas

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Cite this

Okuyama, T., Kitamura, T., Roy, D. S., Itohara, S., & Tonegawa, S. (2016). Ventral CA1 neurons store social memory. Science, 353(6307), 1536-1541. https://doi.org/10.1126/science.aaf7003

Ventral CA1 neurons store social memory. / Okuyama, Teruhiro; Kitamura, Takashi; Roy, Dheeraj S.; Itohara, Shigeyoshi; Tonegawa, Susumu.

In: Science, Vol. 353, No. 6307, 30.09.2016, p. 1536-1541.

Research output: Contribution to journalArticle

Okuyama, T, Kitamura, T, Roy, DS, Itohara, S & Tonegawa, S 2016, 'Ventral CA1 neurons store social memory', Science, vol. 353, no. 6307, pp. 1536-1541. https://doi.org/10.1126/science.aaf7003
Okuyama T, Kitamura T, Roy DS, Itohara S, Tonegawa S. Ventral CA1 neurons store social memory. Science. 2016 Sep 30;353(6307):1536-1541. https://doi.org/10.1126/science.aaf7003
Okuyama, Teruhiro ; Kitamura, Takashi ; Roy, Dheeraj S. ; Itohara, Shigeyoshi ; Tonegawa, Susumu. / Ventral CA1 neurons store social memory. In: Science. 2016 ; Vol. 353, No. 6307. pp. 1536-1541.
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